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相关概念视频

Constitutive and Regulated Gene Expression01:27

Constitutive and Regulated Gene Expression

924
Gene expression in prokaryotes is governed by constitutive and regulated systems, allowing cells to balance the production of essential proteins with adaptive responses to environmental changes.Constitutive Gene ExpressionConstitutive, or housekeeping, genes are continuously expressed as they encode proteins vital for fundamental cellular processes. These include enzymes for glycolysis, ribosomal components for protein synthesis, and proteins involved in DNA replication. Their constant...
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Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
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Coordination of Gene Expression Processes in Bacteria01:29

Coordination of Gene Expression Processes in Bacteria

575
The DNA replication, transcription, and translation processes are intricately coupled in bacteria, allowing efficient gene expression and rapid protein synthesis. While this physical and functional coordination is advantageous, it introduces challenges that bacteria overcome through specific regulatory mechanisms.Coupling of Replication, Transcription, and TranslationThe coupling of replication, transcription, and translation is a hallmark of bacterial gene expression. As the replisome unwinds...
575
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

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Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

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The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
7.9K
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

25.7K
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
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相关实验视频

Updated: Jan 14, 2026

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
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GRiNS:一个用于模拟基因调节网络动态的 Python 库.

Pradyumna Harlapur1, Harshavardhan Bv2, Mohit Kumar Jolly3

  • 1Department of Bioengineering, Indian Institute of Science, Bengaluru, Karnataka, 560012, India.

BMC bioinformatics
|October 17, 2025
PubMed
概括
此摘要是机器生成的。

基因调控相互作用网络模拟器 (GRiNS) 是一个新的Python库,用于高效,可扩展的基因调控网络建模. 它简化了复杂的模拟,使我们能够更好地了解细胞过程.

关键词:
布尔式的伊辛格形式主义形式主义.基因监管网络是基因监管网络.网络动态 网络动态参数不可知模拟的模拟.随机电路扰动 (RACIPE) 是一种随机电路扰动.系统生物学 系统生物学

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科学领域:

  • 计算生物学 计算生物学
  • 系统生物学 系统生物学
  • 生物信息学是一种生物信息学.

背景情况:

  • 基因调节网络 (GRNs) 控制细胞过程,但它们的复杂性挑战了计算建模.
  • 参数化大型GRN模型是计算密集且困难的.

研究的目的:

  • 介绍基因调节交互网络模拟器 (GRiNS),这是一个新的Python库,用于参数无关的GRN建模.
  • 为模拟GRN动态提供可扩展和高效的工具.

主要方法:

  • GRiNS集成了RACIPE (普通微分方程) 和布尔式的Ising形式主义.
  • 该库利用GPU加速来提高模拟性能.
  • GRiNS提供模块化设计,用于可定制的参数选择,初始条件和时间序列输出.

主要成果:

  • 格林斯 (GRiNS) 能够对格林斯网络进行参数无关的模拟,以适应不同的网络大小.
  • 它为使用布尔异常形式主义的大型网络提供了可扩展的替代方案,降低了计算成本.
  • 该库通过RACIPE提高了基于ODE的模拟的准确性和可定制性.

结论:

  • 格林斯 (GRiNS) 方便研究GRN中的动态和稳定态行为,以高效和可扩展的方式.
  • 该工具支持复杂生物系统的参数不可知建模方法.
  • 可访问的文档和安装指南可以在网上找到.