综合微生物组和代谢组分析揭示了在牛皮病的发病过程中的微生物-代谢相互作用
Fan Wu1,2, Xin Jiang3, Guanzhi Chen4
1Qingdao University, Qingdao, China.
BMC microbiology
|October 17, 2025
概括
牛皮涉及改变的皮肤微生物和新陈代谢. 减少Cutibacterium和增加Staphylococcus/Corynebacterium与炎症和氧化应激相关,影响牛皮的发展.
科学领域:
- 皮肤病学 皮肤病学
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 系统生物学 系统生物学
背景情况:
- 牛皮是一种慢性炎症性皮肤病,原因不明.
- 皮肤微生物组和皮肤牛皮中的代谢变化的作用尚未完全理解.
研究的目的:
- 为了研究皮肤微生物组和牛皮中的代谢组之间的相互作用.
- 为了识别与牛皮病原发生相关的微生物和代谢特征.
主要方法:
- 在29名牛皮患者和31名对照患者的皮肤微生物组 (16S rRNA测序) 和非向代谢学 (LC-MS/MS) 的综合分析.
- 多变量统计和相关性分析,以识别不同的微生物,代谢物及其相互作用.
主要成果:
- 牛皮病变显示出更高的微生物多样性,不同的社区结构,丰富的Corynebacterium/Staphylococcus和减少的Cutibacterium.
- 确定了63种不同的代谢物,主要在脂质,氨基酸和炎症途径中.
- 微生物失生与代谢变化相关;Cutibacterium与减少炎症和增加抗氧化剂有关,而Staphylococcus/Corynebacterium显示了相反的模式.
结论:
- 皮肤微生物组和代谢组的显著变化是牛皮的特征.
- 微生物-代谢物相互作用表明,通过脂质代谢,炎症和氧化应激调节,抗生素有助于牛皮.
- 减少的Cutibacterium和增加的Staphylococcus/Corynebacterium可能在牛皮的发病过程中发挥关键作用.
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