乳酸菌 (Lactobacillus rhamnosus B16) 通过产生酸来调节脂质代谢的恒常性
Zhengping Che1,2, Juan Huang1, Shiyi Wen1
1Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, Guangdong Medical University, Dongguan, 523808, China.
Journal of translational medicine
|October 17, 2025
概括
一种新的Lactobacillus rhamnosus菌株,L. rB16,有效地降低了超脂症小鼠的胆固醇. 这种益生菌利用乙激活LXRα通路,显示出治疗脂质代谢障碍的潜力.
科学领域:
- 微生物学和肠道健康
- 代谢障碍 代谢障碍 代谢障碍
- 益生菌研究 益生菌研究
背景情况:
- 超脂血症带来显著的心血管风险,目前的治疗方法有局限性.
- 针对脂质代谢障碍,正在探索新的治疗策略,包括像Lactobacillus rhamnosus这样的益生菌.
- 在脂质调节中益生菌作用的精确机制需要进一步阐明.
研究的目的:
- 为了识别和表征一种具有降胆固醇特性的新型Lactobacillus rhamnosus菌株.
- 调查鉴定的益生菌菌株的脂质调节效应背后的分子机制.
- 在超脂血症的体内模型中评估益生菌的疗效.
主要方法:
- 从人类便中分离和识别了一种新型Lactobacillus rhamnosus菌株 (L. rB16).
- 在体外测试包括胆固醇降解,胃肠道耐受性和生物膜形成.
- 分析L. rB16对泡细胞中的脂质代谢相关蛋白质 (LXRα,ABCA1,ABCG1,HMGCR,SREBP1) 的作用.
- 使用高脂肪饮食诱导的超脂血症小鼠模型的体内研究,包括血清脂质分析和组织学分析.
- 代谢和短链脂肪酸分析以确定关键代谢物.
主要成果:
- 一种新的Lactobacillus rhamnosus菌株,L. rB16,在体外被确定具有显著的降胆固醇能力.
- 热失活的L.rB16 (HI-L.rB16) 通过肝X受体α (LXRα) 信号通路减少泡细胞中的胆固醇.
- 代谢分析发现HI-L产生的酸.rB16是负责降低胆固醇的主要代谢物.
- 通过调节关键的脂质相关蛋白质,HI-L.rB16调节了肝脏脂质代谢.
结论:
- 热不活化的L.rB16减轻了小鼠的高脂肪饮食引起的高脂血症.
- 降低胆固醇的效果是由LXRα信号通路的酸盐诱导激活介导的.
- 作为一种治疗脂质代谢障碍的益生菌,L.rB16显示出显著的治疗潜力.
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