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拉布拉多猎犬小狗的肠道微生物群:一个纵向队列研究

Charlotte S C Woolley¹, Adrian Muwonge², Barend M de C Bronsvoort²

¹Centre for Epidemiology Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, M13 9PL, UK. charlotte.woolley@manchester.ac.uk.

Animal microbiome

|October 18, 2025

概括

这项研究追踪了拉布拉多犬幼犬的狗肠道微生物群随着时间的推移. 影响小狗肠道细菌的关键因素包括饮食,抗生素使用和胃肠道健康,为所有者和兽医提供了见解.

科学领域:

兽医医学兽医医学兽医医学
微生物组研究微生物组研究
动物卫生动物健康

背景情况:

有限的纵向数据存在于狗肠道微生物群的发展.
外部因素对小狗肠道微生物群的影响需要进一步探索.

研究的目的:

为了纵向描述拉布拉多犬幼犬的肠道微生物群发育.
确定肠道微生物群与人口,生活方式,抗生素和健康因素之间的关联.

主要方法:

招募了76只拉布拉多猎犬小狗参加英国的队列研究.
收集的便样本在3至4个月,7个月和12个月为16S rRNA基因测序.
使用线性混合效应模型,PERMANOVA和多变量关联模型分析数据.

主要成果:

狗狗的肠道微生物群组成因年龄,性别,饮食 (coprophagia),抗生素使用和胃肠道问题 (腹,吐) 而异.
抗生素的使用暂时减少了α多样性和改变了微生物组成.
个人身份是肠道微生物群变化的最大来源.

结论:

纵向采样对于了解狗肠道微生物群的发展至关重要.
确定了影响小狗肠道微生物群的关键因素,为物主人和兽医提供了洞察力.
建立了对因果机制和干预措施未来研究的基础.

关键词:

16S rRNA 是一个16S rRNA.流行病学流行病学拉布拉多回收犬是什么意思纵向研究是指长度研究.

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