萨克格拉巴特A/B,芳香的潘塔诺林登安塞斯基特尔佩诺伊德Dimer来自Sarcandra glabra的
Danyang Zhang1, Pengfei Tang1, Yi Zhu1
1Basic Medical Research Innovation Center for Anti-Cancer Drugs, MOE and Jiangsu Key Laboratory of Bioactive Natural Product Research, China Pharmaceutical University, 639 Longmian Dadao, Nanjing 211198, China.
Organic letters
|October 18, 2025
概括
从Sarcandra glabra中分离出六种新的lindenane sesquiterpenoid二次体,Sarcglabates A-F,这些二次体是从Sarcandra glabra中分离出来的. 化合物6通过抑制IL-1β和P65激活显示出抗炎作用.
科学领域:
- 自然产品化学 自然产品化学
- 有机化学 有机化学
- 药理学 药理学是指药理学的学科.
背景情况:
- Sarcandra glabra是一种传统的药用草本.
- 类二次体是复杂的自然产物,具有多样化的生物活动.
研究的目的:
- 从Sarcandra glabra中分离和表征新型的状状二次体.
- 为了评估分离的化合物的抗炎潜力.
主要方法:
- 使用色谱技术进行隔离和净化.
- 通过高分辨率质谱 (HR-MS),核磁共振 (NMR) 和电子圆形二元化 (ECD) 阐明结构.
- 通过单晶X射线衍射来验证结构.
- 在体外查,以检测对互乐素-1β (IL-1β) 的抑制作用.
主要成果:
- 鉴定了六个lindenane sesquiterpenoid二次体,Sarcglabates A-F (1-6),其中包括两个前所未有的骨.
- 化合物1-2具有独特的芳香型色林登二元结构,具有6/5/6骨架和环.
- 化合物3-5表现出四基与合的林登结构.
- 化合物6显示显著抑制IL-1β和抑制P65激活,表明抗炎活性.
结论:
- 这项研究成功地从Sarcandra glabra中分离和表征了新型的lindenane sesquiterpenoid二次体.
- 萨克格拉巴特F (6) 显示出有前途的抗炎性质,需要进一步研究治疗潜力.
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