这是谁的线? 确定传染病监测的血清阳性截止值
Michael T White1, Gaëlle Baudemont1, Françoise Donnadieu1
1Infectious Disease Epidemiology and Analytics G5 Unit, Department of Global Health, Institut Pasteur, Université Paris-Cité, INSERM U1347, Paris, France.
The Journal of infectious diseases
|October 18, 2025
概括
确定血清阳性截止值对于传染病监测至关重要. 一个新的框架指导了对抗体数据解释的适当方法的选择,在各种环境中提高了可靠性.
科学领域:
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 血清测定对于通过测量抗体反应来跟踪传染病至关重要.
- 确定的精确的血清阳性截止值是一个重要的方法障碍.
研究的目的:
- 根据试验特征,样本可用性和预期用途选择血清阳性截止值的框架.
- 为在血清学调查中选择合适的抗体数据解释方法提供指导.
主要方法:
- 评估了四种方法:接收器操作特征 (ROC) 曲线,负样本分布,正样本分布和混合模型.
- 每种方法的详细假设,优势和局限性.
- 将框架应用于模拟数据和多重血清学调查数据,用于被忽视的热带疾病.
主要成果:
- 证明单一的方法对所有病原体或种群来说是不够的.
- 突出混因素,如交叉反应性抗体,人群特异性IgG水平和测试特征.
- 使用模拟和现实世界血清学数据的插图框架应用.
结论:
- 支持依赖上下文的,基于证据的切断方法的选择,使用确认的样本.
- 强调需要强大的框架来解释来自多重血清平台的抗体数据.
- 提出了一个务实的框架,以提高血清流行病学见解的可靠性和可比性.
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