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唾液和血清脂聚糖活性的口腔微生物决定因素

M Manzoor¹, J Putaala², S Zaric³

¹Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.

Journal of dental research

|October 18, 2025

概括

口腔微生物组失生症增加了唾液和血清中的脂多糖 (LPS) 活性. 这项研究将特定的口腔细菌和代谢途径与LPS水平联系起来,突出显示了口腔微生物群.

科学领域:

微生物组研究的研究.
口腔健康口腔健康
免疫学免疫学免疫学

背景情况:

脂聚糖 (LPS) 是格拉姆阴性细菌的一个关键毒性因子.
腰椎病变转位和内毒性病与口腔和全身疾病有关.
口腔微生物组组成和LPS活性之间的联系尚未得到充分理解.

研究的目的:

研究口腔微生物群多样性,分类学和功能与唾液和血清LPS水平之间的关联.
为了确定与LPS活动相关的特定微生物种群和代谢途径.
了解口腔微生物群在内毒性病中的作用.

主要方法:

来自298个人的唾液的元基因组测序.
测量血清和唾液中LPS活动.
多变量线性回归和MaAsLin2用于关联分析.

主要成果:

唾液α多样性与唾液LPS,吸烟和抗生素使用负相关.
口腔微生物群体的组成在唾液LPS三角体之间有显著差异.
鉴定了10种与血清LPS相关的口腔种群和59种与唾液LPS相关的种群,包括Prevotella和Porphyromonas.
参与LPS生物合成的微生物代谢途径与唾液LPS活性有关.

结论:

口腔微生物组失调是增加唾液和血清LPS活动的重要来源.
特定的口腔种群和代谢功能与LPS水平有关.
研究结果表明,口腔微生物组在调节系统性LPS暴露和相关病理方面发挥着至关重要的作用.

关键词:

生物标志物生物标志物结尾性毒性病 (endotoxemia) 是一种导致内毒的疾病.格拉姆阴性细菌是一种细菌.大基因组测序的测序.口腔的微生物群.牙周炎是指牙周炎的一种疾病.

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