跨越关节结构,功能和疼痛:一个综合的多层次视角
P Chen1,2, M C Embree3,4, M-K Chung5
1Clemson-MUSC Bioengineering Program, Department of Bioengineering, Clemson University, Clemson, SC, USA.
Journal of dental research
|October 18, 2025
概括
关节 (TMJ) 功能障碍涉及结构,功能和疼痛之间的复杂相互作用. 使用多层次框架整合这些因素是了解关节疾病和开发更好的治疗方法的关键.
科学领域:
- 生物医学工程 生物医学工程
- 神经科学是一个神经科学.
- 类风湿病学 类风湿病学
背景情况:
- 关节 (TMJ) 疾病的特点是与功能障碍和疼痛相关的结构性改变.
- 目前对TMJ疼痛机制及其与结构和功能变化的关系的理解有限.
- 关于关节结构,功能和疼痛的研究历史上一直是分散的,阻碍了整合性的洞察力.
研究的目的:
- 综合有关TMJ结构,功能和不同尺度和模型的疼痛的当前知识.
- 提出一个新的多尺度和多物理框架来评估TMJ动态.
- 弥合分散的研究领域,以全面了解关节疾病.
主要方法:
- 审查和综合现有的人类和动物模型研究TMJ结构,功能和疼痛.
- 分析TMJ的细胞,细胞外和神经元件的多尺度时空变化.
- 生物机械,生物化学,细胞,感知和心理社会因素的整合.
主要成果:
- 关节疾病涉及机械负载,神经反应,免疫信号和大脑调节之间的复杂,双向相互作用.
- 结构变化,功能障碍和面疼痛之间的现有临床相关性是不一致的.
- 一个拟议的多层次框架可以全面评估动态的TMJ过程.
结论:
- 综合,多层次的方法对于阐明关节疾病机制和疼痛慢性是必不可少的.
- 这一框架有望改善关节疾病的诊断和指导向治疗.
- 需要跨学科的合作和先进的方法来实现这种综合方法.
相关概念视频
01:03Structural Joints: Fibrous Joints
Fibrous joints are a type of joint where the bones are connected by fibrous connective tissue. These joints provide stability and minimal to no movement between the articulating bones. There are three types of fibrous joints.
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Suture
All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...
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There are two types of cartilaginous joints:
Synchondrosis
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