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地中海生活方式与慢性病风险降低之间的关联:基于人口的前性研究
Hyo Jeong Kim1, Hee Byung Koh2, Chan-Young Jung3
1Department of Internal Medicine, Yonsei University College of Medicine, Institute of Kidney Disease Research, Seoul, Republic of Korea; Division of Nephrology, Department of Internal Medicine, Gangnam Severance Hospital, Seoul, Republic of Korea.
Mayo Clinic proceedings
|October 18, 2025
概括
采用地中海生活方式,以MEDLIFE指数衡量,与患慢性病 (CKD) 的风险降低有关. 更严格地遵守地中海饮食和习惯可以显著降低CKD发病率.
科学领域:
- 流行病学 流行病学
- 预防医学 预防医学
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 慢性病 (CKD) 构成了全球健康的重大负担.
- 生活方式因素越来越多地被认为是CKD的可修改风险因素.
- 地中海生活方式指数 (MEDLIFE) 综合了饮食和生活方式的组成部分.
研究的目的:
- 检查坚持地中海生活方式与慢性病发病率之间的关联.
- 量化与更高的MEDLIFE指数得分相关的CKD风险降低.
主要方法:
- 一项前性观察性研究利用英国生物库数据从158,080名没有CKD的参与者.
- 地中海生活方式 (MEDLIFE) 指数,包括饮食,习惯和身体活动,被用作主要预测指标.
- 考克斯的比例危险模型被用来评估MEDLIFE指数和事件CKD之间的关联.
主要成果:
- 较高的MEDLIFE指数得分与更健康的基线特征相关 (较低的BMI,血压,较少的糖尿病/高血压).
- 在11.2年的随访期间,记录了4354例发生性CKD病例.
- 梅德利夫指数每增加1个点,就会使CKD风险降低6% (aHR=0.94). 在最高四分位数的参与者与最低四分位数的参与者相比,风险降低了35%.
结论:
- 较高的地中海生活方式指数 (MEDLIFE) 与发生慢性病的风险显著降低有关.
- 这些发现支持促进地中海生活方式的模式,以预防病.
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