类似的症状,不同的综合征:对IBD-IBS重叠患者的多模式方法
Andrew Chang1, Janice Oh2, Andrea Shin2
1Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, UCLA School of Medicine, Los Angeles, 757 Westwood Plaza, Los Angeles, CA, 90095, USA. andchang@mednet.ucla.edu.
Digestive diseases and sciences
|October 18, 2025
概括
炎症性肠病 (IBD) 和刺激性肠综合征 (IBS) 具有共同的症状. 本综述探讨了IBD-IBS重叠机制,并提出了针对持续性胃肠道问题的多式疗法.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
背景情况:
- 炎症性肠病 (IBD) 和刺激性肠综合征 (IBS) 是不同的胃肠道疾病.
- 这两种情况都经常出现重叠的症状,如腹痛和肠道习惯的改变.
- IBD涉及慢性炎症,而IBS的特点是没有炎症的症状.
研究的目的:
- 审查IBD和IBS的共同潜在机制.
- 解决IBD-IBS重叠所带来的诊断和治疗挑战.
- 概述IBD-IBS重叠患者的综合性多模式治疗策略.
主要方法:
- 文献综述综合了IBD和IBS的新兴证据.
- 分析共享的病理生理机制,包括免疫激活,屏障功能障碍和肠-大脑轴.
- 检查微生物组的变化及其作用.
主要成果:
- IBD-IBS重叠症状可能源于持续的免疫激活,障碍障碍功能,内脏过敏,肠-大脑轴功能障碍或微生物组变化.
- 共同的机制有助于症状持续,即使在IBD炎症缓解后.
- 为了有效的管理,需要采用多模式的方法.
结论:
- 了解共享机制对于管理IBD-IBS重叠至关重要.
- 建议采用多模式治疗方法,整合药物,饮食,心身和微生物组导向的策略.
- 对这些共享途径的进一步研究可以改善患者的治疗结果.
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