在Helicobacter pylori根除疗法期间,氧化剂和抗氧化剂相关的微量元素水平的变化
Ching-Chiang Lin1,2,3, Ming-Kun Ku4, Hsueh-Chiao Liu1
1Department of Laboratory Medicine, Fooyin University Hospital, Pingtung, Taiwan.
Biological trace element research
|October 18, 2025
概括
杆菌根除疗法改变了微量元素水平和甲 (MDA),表明氧化应激增加. 需要进一步的研究来了解这些变化的临床影响.
科学领域:
- 生物化学 生物化学
- 临床医学 临床医学
- 微生物学 微生物学
背景情况:
- 杆菌 (H. pylori) 感染是胃炎,胃潰瘍和胃癌的主要原因.
- 建议进行根除疗法,以预防与H. pylori相关的并发症.
- 微量元素在氧化平衡中起着至关重要的作用,它们的水平在H. pylori治疗期间可能会发生变化.
研究的目的:
- 在接受H. pylori根除治疗的患者中,研究七种关键微量元素和氧化应激标记物马隆迪化 (MDA) 的变化.
- 探索对H. pylori根除疗法的代谢反应,涉及微量元素稳态和氧化应激.
主要方法:
- 血液和尿液样本从40名患者在基线和治疗后一个月内收集.
- 使用ICP-MS或AAS测量微量元素度.
- 使用HPLC-FLD确定MDA水平.
- 通过尿素呼吸试验证实了H. pylori的根除.
主要成果:
- 铁,铜,和MDA的血水平在治疗后显著增加 (p <0.05).
- 血中和水平在治疗后显著下降 (p < 0.05).
- 尿液中铁,铜,和的度显著下降,而的度增加 (p < 0.05).
- 血液尿素增加 (p = 0.007),但其他血液学和化学参数基本保持不变.
结论:
- 杆菌根除疗法显著改变了益氧化剂和抗氧化剂微量元素的水平,以及MDA.
- 这些变化表明,在根除疗法后,氧化应激增加.
- 需要进一步研究以阐明这些观察到的变化的临床意义.
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