黄素补充剂对精神分裂症治疗的影响:随机对照试验的系统审查和元分析
Mariano Gallo Ruelas1, Fernanda Ribeiro de Lima2, Giovanna Hanike Santos da Silva3
1Instituto de Investigación Nutricional (IIN), Lima, Peru. marianorgr@gmail.com.
The Psychiatric quarterly
|October 18, 2025
概括
当与标准治疗一起使用时,黄素可能会略微减少精神分裂症患者的负面症状. 然而,证据有限,它没有显著影响积极的症状或抑郁症,这需要进一步的研究.
科学领域:
- 精神病学和行为科学
- 药理学 药理学是指药理学的学科.
- 基于证据的医学基于证据的医学.
背景情况:
- 负面症状在精神分裂症管理中构成了重大挑战.
- 目前针对负面症状的药物治疗方法有限.
- 黄素显示出作为负面症状的辅助疗法的潜力,但临床证据需要评估.
研究的目的:
- 系统地审查和元分析随机对照试验 (RCT) 关于黄素在精神分裂症和其他精神疾病中的作用.
- 评估黄素作为各种症状领域标准治疗的辅助剂的疗效.
主要方法:
- 在主要数据库 (PubMed,Scopus,Web of Science,Cochrane Library) 进行系统搜索,截至2024年5月.
- 仅包括研究黄素干预的RCT.
- 使用GRADE方法评估证据确定性.
主要成果:
- 包括四个涉及精神分裂症患者的RCT.
- 黄素显示了负面症状 (SMD -0.37,低Coe) 和一般精神病理 (SMD -0.68,非常低Coe) 的统计学显著下降.
- 对于积极症状 (低Coe),总症状 (非常低Coe) 或抑郁症 (非常低Coe) 没有发现显著影响.
结论:
- 黄素补充剂在辅助使用时,可能对精神分裂症的负面症状提供适度的益处.
- 证据的确定性低至非常低,限制了对影响估计的信心.
- 临床实施尚未推;需要进一步研究负面症状的分子标.
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