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Updated: Jan 14, 2026

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
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在Ahp-Bicyclodepsipeptides生物合成中的侧链宏循环化涉及P450细胞染色体催化序列芳香化和C─N合

Qiang Dong1, Niandi Zhang2, Xiaorong Chen1

  • 1Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, Guangdong, 528400, China.

Angewandte Chemie (International ed. in English)
|October 18, 2025
PubMed
概括

这项研究详细介绍了由细胞染色体P450单氧化酶 (CYP450) 酶催化的自行车载酸FR901277和德尔摩素A2的生物合成. 这项研究揭示了一种新的C-N键形成机制,对于自然产品中的宏观循环构造至关重要.

关键词:
生物合成生物合成在C─N合器.基因组开采是为了挖掘基因组.非核糖体类的.侧链宏环化侧链宏环化

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