相关实验视频

Updated: Jul 18, 2026

Mapping Genome-wide Accessible Chromatin in Primary Human T Lymphocytes by ATAC-Seq
09:08

Mapping Genome-wide Accessible Chromatin in Primary Human T Lymphocytes by ATAC-Seq

Published on: November 13, 2017

发现与ATAC-seq足迹传导转录因子结合因子相关的遗传变异的协议

Max F Dudek1, Brandon M Wenz2, Benjamin F Voight3

  • 1Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Graduate Group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

STAR protocols
|October 18, 2025
PubMed
概括

这项研究引入了一种计算方法,用于识别与转录因子 (TF) 结合相关的遗传变异,使用测试转化酶可访问的染色质使用测序 (ATAC-seq) 数据. 该协议有助于确定疾病相关区域的因果变异.

关键词:
生物信息学是一种生物信息学.遗传学 是一个遗传学.测序测序是指测序的时间.

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相关概念视频

Chromatin Immunoprecipitation- ChIP02:36

Chromatin Immunoprecipitation- ChIP

Chromatin immunoprecipitation, or ChIP, is an antibody-based technique used to identify sites on DNA that bind to transcription factors of interest or histone proteins. It also helps determine the type of histone modifications such as acetylation, phosphorylation, or methylation.
Types of ChIP
ChIP can be divided into two types - X-ChIP and N-ChIP. X-ChIP involves in vivo cross-linking of histones and regulatory proteins to DNA, fragmenting the DNA by sonication, and isolating the protein-DNA...