在子宫内膜异位症中血清孕激素度和皮下孕激素补充:人工循环冷胚胎移植
Noemie Sachs-Guedj1, Buenaventura Coroleu2, Manuel Álvarez2
1Dexeus Fertility, Department of Obstetrics Gynecology and Reproductive Medicine, Hospital Universitari Dexeus, Barcelona, Spain.; Autonomous University of Barcelona, Department of Pediatrics - Obstetrics and Gynecology - Faculty of Medicine, Barcelona, Spain.
Reproductive biomedicine online
|October 18, 2025
概括
与对照人群相比,子宫内膜异位症患者在冷胚胎移植前的孕激素水平与对照人群相似. 皮下孕激素补充剂导致可比的活产率,不论子宫内膜异位状态,表明有效的质期支持.
科学领域:
- 生殖内分泌学和不孕不育问题
- 辅助生殖技术 辅助生殖技术
- 子宫内膜异位症研究研究
背景情况:
- 在辅助生殖技术后,孕激素对于成功怀孕至关重要.
- 子宫内膜异位症可能会影响生殖结果和荷尔蒙特征.
- 在人工循环冷胚胎移植 (AC-FET) 中,最佳的质阶段支持是必不可少的.
研究的目的:
- 为了比较经过AC-FET的带有和没有子宫内膜异位症的患者之间转移前的孕激素度.
- 评估 AC-FET 周期的活产率 (LBR) 在不同孕激素水平和补充剂的情况下,考虑到子宫内膜异位症状态.
- 为了确定皮下孕激素补充是否对子宫内膜异位症患者的LBR产生不同的影响.
主要方法:
- 使用阴道孕激素进行的985个AC-FET周期的回顾性队列研究.
- 患者根据子宫内膜异位症诊断和转移前的孕激素水平 (<10.6 ng/ml或≥10.6 ng/ml) 分类.
- 皮下孕激素被用于<10.6 ng/ml的水平;LBR在四个定义的组中被分析.
主要成果:
- 在子宫内膜异位症和对照组 (aOR 0.98) 中,转移前的孕激素水平与子宫内膜异位症和对照组相比较.
- 在调整了混因素后,所有四组的活产率都相似.
- 在怀孕测试日的更高的孕激素水平与两组临床怀孕和LBR的增加相关.
结论:
- 在冷胚胎移植前的孕激素度在患有内膜异位症和没有内膜异位症的患者中是相似的.
- 阴道孕激素与指示的皮下补充剂相结合,可以实现可比的活产率,不论子宫内膜异位症.
- 这种疗法在不同患者群体中为AC-FET周期提供有效的质阶段支持.
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