在益生菌瘤的卡伯戈林治疗期间IGF-1水平的动态变化
Ahmet Numan Demir1, Alara Birol2, Dilan Ozaydin3
1Department of Endocrinology, Metabolism, and Diabetes, Istanbul University-Cerrahpasa, Istanbul, Turkey.
概括
卡伯戈林治疗前乳腺瘤可能最初会增加,然后降低胰岛素样生长因子-1 (IGF-1) 水平. 较长的治疗时间和较高的剂量与IGF-1的减少相关,尽管临床意义需要进一步研究.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 在瘤学瘤学.
背景情况:
- 卡伯戈林是一种多巴胺激动剂,用于治疗乳腺癌.
- 它对胰岛素样生长因子-1 (IGF-1) 对前乳腺瘤患者的长期影响尚不清楚.
- 众所周知,卡伯戈林可以抑制生长激素 (GH) 和IGF-1.
研究的目的:
- 为了评估IGF-1水平在接受cabergoline的前乳腺瘤患者的变化.
- 确定影响这些IGF-1水平变化的因素.
- 评估卡贝戈林剂量,治疗持续时间和IGF-1水平之间的关系.
主要方法:
- 对127名用卡伯戈林 (2013-2023) 治疗的益生菌瘤患者进行了回顾性队列研究.
- 排除患有影响IGF-1的疾病的患者.
- 基线IGF-1和IGF-1xULN水平的比较和最后的随访.
- 回归和ROC分析以评估与治疗持续时间,累积剂量和瘤特征的关联.
主要成果:
- 随访时间中位数为36个月.
- 最终的IGF-1和IGF-1xULN水平明显低于基线 (p < 0.05).
- 降低IGF-1xULN与更长的治疗时间和更高的累积卡伯戈林剂量 (p <0.05) 有关.
- 降低IGF-1的预测因素包括累积剂量≥60mg和治疗持续时间≥18个月.
结论:
- 卡伯戈林治疗益生菌瘤可能会导致IGF-1水平初步上升,随后下降.
- 即使在正常范围内,IGF-1的减少也需要进一步研究.
- 需要有明确的代谢终点的前性研究来澄清临床意义.
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