肠道甘氨酸对血甘氨酸和重症患者的肌肉结构,大小和功能的影响:一项随机对照试验
Yasmine Ali Abdelhamid1, Amy J Bongetti2, Marissa K Caldow2
1Intensive Care Unit, Royal Melbourne Hospital, Melbourne, Australia; Department of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, Australia.
Clinical nutrition (Edinburgh, Scotland)
|October 18, 2025
概括
接受高剂量甘氨酸的重症患者表现出血和肌肉甘氨酸水平的增加. 需要进一步的研究来确认甘氨酸.
科学领域:
- 关键护理医学 关键护理医学
- 营养科学 营养科学
- 肌肉生理学 肌肉生理学
背景情况:
- 危急病患者经常经历显著的肌肉损失和身体损伤.
- 临床前研究表明,补充甘氨酸可以减轻肌肉损耗.
研究的目的:
- 评估重症患者中肠道甘氨酸的血可用性.
- 为了确定糖氨酸补充剂对关键疾病期间肌肉损失的影响.
主要方法:
- 一个盲目的随机临床试验,涉及机械通风患者.
- 患者接受低剂量甘氨酸 (0.2 g/kg/天),高剂量甘氨酸 (0.4 g/kg/天) 或安慰剂,长达7天.
- 分析了血甘氨酸水平,肌肉厚度 (超声波) 和肌肉活检.
主要成果:
- 高剂量的甘氨酸显著增加了血和肌肉甘氨酸度,以剂量依赖的方式.
- 随着高剂量甘氨酸的使用,观察到减少四头肌肉厚度损失的趋势.
- 糖氨酸补充剂没有影响肌纤维直径,但与更短的ICU和住院时间有关.
结论:
- 在重症患者中,补充甘氨酸有效地提高了血和肌肉甘氨酸度.
- 甘氨酸对减少严重疾病中的肌肉损失的潜在益处需要在更大规模的试验中进一步调查.
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