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在桃切除术中经过手术后给予凯托洛拉克的出血潜力和有效性:系统性综述和元分析
Do Hyun Kim1, David W Jang2, Se Hwan Hwang3
1Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
International journal of pediatric otorhinolaryngology
|October 18, 2025
概括
在桃体切除术中,外科手术期间使用的桃体并没有增加儿童或成人出血风险. 这种疼痛管理策略有效地减少了术后的恶心,吐和止痛药的使用.
科学领域:
- 麻醉学和疼痛管理
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
背景情况:
- 桃体切除术是一种常见的外科手术,与显著的术后疼痛和潜在的并发症有关.
- 有效的疼痛管理和尽量减少副作用对于桃体切除术后的患者康复至关重要.
研究的目的:
- 为了评估经过桃体切除术的患者的外科手术期间 ketorolac 的安全性和有效性.
- 评估凯托洛拉克对术后疼痛,止痛药消耗,恶心,吐和出血率的影响.
主要方法:
- 进行了对15项涉及1249名患者 (儿科和成人) 的研究的系统审查和元分析.
- 研究比较了外科手术期间的凯托洛拉克与控制干预措施 (盐水,乙氨基,阿片类药物).
- 结果包括疼痛评分,止痛药的使用,以及恶心,吐和出血的发生率.
主要成果:
- 与对照组相比,托洛拉克的使用并没有显著增加初级或二次术后出血的发生率.
- 在基托洛拉克组 (OR=0.61) 观察到术后恶心和吐的显著减少.
- 凯托洛拉克有效降低了术后疼痛和所需的整体止痛药物的数量.
结论:
- 在外科手术期间,桃体切除术似乎是安全的,没有显著增加出血风险.
- 凯托洛拉克在改善早期疼痛控制和减少术后恶心和吐方面表现出有效性.
- 需要进行进一步的研究,以最终证实出血发生率的安全概况.
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