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比克特格拉维尔/埃姆特里西塔宾/特诺福维尔阿拉芬胺固剂组合在晚期艾滋病毒疾病中
Diego Cecchini1, Carla Serrano2, Martín Brizuela1
1Helios Salud, Buenos Aires, Argentina.
Medicina
|October 18, 2025
概括
双重/emtricitabine/tenofovir alafenamide (B/F/TAF) 在艾滋病毒感染者 (PLWH) 患有晚期艾滋病毒疾病 (AHD) 的人群中显示出高安全性和持续性. 这种组合疗法有效地改善了病毒抑制和CD4计数,无论是在治疗新手和经验丰富的人群中.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 药理学 药理学是指药理学的学科.
背景情况:
- 比克特格拉维尔/emtricitabine/tenofovir alafenamide (B/F/TAF) 是一种联合抗逆转录病毒疗法.
- 现实世界的数据表明,与B/F/TAF一起的高病毒抑制 (VS) 在未经治疗 (TN) 和经过治疗 (TE) 的艾滋病毒感染者 (PLWH) 中.
- 这项BIC-CD4研究专门研究了晚期艾滋病毒疾病 (AHD) 的PLWH中的B/F/TAF,定义为CD4计数<200细胞/mm3.3,定义为CD4计数<200细胞/mm3.
研究的目的:
- 为了评估B/F/TAF的安全性,持久性和病毒抑制 (VS) 在PLWH中,开始用CD4计数低于200细胞/mm3.4的治疗.
- 描述TN和TEPLWH的特征和结果,其中AHD开始于B/F/TAF.
- 评估B/F/TAF对该人群中CD4+T细胞恢复的影响.
主要方法:
- 追溯性,多站点,观察性,开放的队列研究.
- 包括在2019年10月至2024年1月期间发起B/F/TAF的TN和TE PLWH.
- 来自阿根廷三个艾滋病毒诊所收集的数据.
主要成果:
- 在开始B/F/TAF的3527名患者中,有250名 (7%) 患有AHD (CD4 <200/mm3).
- 对于TN患者 (n=132),48周持久性为99%,VS为83%,CD4的中位数从94增加到284/mm3.
- 对于TE患者 (n=117),48周的VS率为不可检测 (TEU) 亚组的98%和不可检测 (TENU) 亚组的89%,整体持久性>99%和CD4计数的改善. 没有报告任何不良事件.
结论:
- B/F/TAF在有AHD的PLWH中显示出出色的安全性和持久性.
- 组合疗法实现了足够的病毒抑制,并促进了 CD4 + T 细胞的恢复,无论是在未经治疗的和经验丰富的艾滋病毒晚期患者中.
- B/F/TAF是一种可行和有效的治疗选择,用于呈现先进的艾滋病毒疾病的PLWH.
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