肠道微生物Bacteroides acidifaciens可以改善CCl4诱导的肝纤维化
Fangyu Ye1, Yingjian Hou2, Min Huang1
1School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 211198, Nanjing, China.
European journal of pharmacology
|October 18, 2025
概括
细菌酸菌及其代谢物,短链脂肪酸 (SCFA),有效地治疗小鼠肝纤维化. 这种肠道细菌及其SCFA通过减少炎症和调节免疫细胞,为肝纤维化提供了一种新的治疗策略.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 肝纤维化是一种与慢性肝病相关的进展性疾病.
- 肠道微生物群通过肠-肝轴在肝纤维化进展中发挥作用.
- 在之前的研究中,黄化合物GL-V9在缓解肝纤维化方面表现出有效性.
研究的目的:
- 为了研究GL-V9治疗肝纤维化小鼠的肠道微生物群变化.
- 为了确定具有抗纤维素潜力的特定细菌物种.
- 探索已识别的细菌及其代谢物的治疗机制.
主要方法:
- 16S rRNA基因测序用于分析肠道微生物的特征.
- 建立和治疗肝纤维化的小鼠模型.
- 评估纤维化和炎症标志物,调节性T (Treg) 细胞透和短链脂肪酸 (SCFA) 含量.
主要成果:
- 鉴定出Bacteroides acidifaciens是与GL-V9治疗相关的一个关键细菌.
- 口服Bacteroides acidifaciens减轻了肝纤维化,减少了炎症,并抑制了Treg细胞透.
- 细菌酸菌衍生的SCFA显示出抗纤维和抗炎作用,调节PI3K/AKT/mTOR通路.
结论:
- 细菌酸菌及其衍生SCFA具有显著的抗纤维性质.
- 这些发现表明肝纤维化治疗的新治疗途径.
- 这项研究强调了肠道微生物群在治疗肝纤维化中的作用.
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