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尽管接种了疫苗,但甲型肝炎的突破性感染:系统审查和元分析
Jenny L Schnyder1, David Hutten1, Bache E Bache1
1Center for Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Amsterdam University Medical Centers, location AMC, Amsterdam Public Health - Global Health, Amsterdam Institute for Immunology and Infectious Diseases, University of Amsterdam, Amsterdam, The Netherlands.
在接种疫苗的人群中,甲型肝炎 (HepA) 突破性感染并不常见. 然而,免疫受损人群 (ICPs) 更频繁地经历这些突破性HepA感染,特别是如果他们在接种疫苗后没有发展出足够的免疫力.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 肝炎A (HepA) 疫苗接种对于预防感染至关重要.
- 在接种疫苗的人群中发生的突破性感染需要进一步调查.
- 免疫受损人群 (ICP) 可能会改变疫苗反应.
研究的目的:
- 系统地审查和分析记录的突破性甲型肝炎 (HepA) 感染.
- 为了确定突破性HepA感染是否在免疫受损人群 (ICPs) 中更为普遍.
主要方法:
- 在Medline,Embase和全球指数Medicus中搜索了HepA突破性感染 (1991-2024年).
- 包括的研究将突破定义为先前接种疫苗的个体的症状性肝炎炎.
- 分析了使用随机效应和贝叶斯分层元分析的中等和优质研究.
主要成果:
- 包括90份报告,43,861例HepA病例,其中832例是接种疫苗的.
- 确定了六个确定的突破性肝炎A感染 (6.4%),其中四个 (67%) 发生在ICP中.
- 在所有确诊的肝炎炎病例中,ICP的整体比例为17.8%.
结论:
- 甲型肝炎 (HepA) 突破性感染很罕见,但已有记录.
- 突破性HepA感染在免疫受损人群 (ICPs) 中更为常见.
- 在接种疫苗后未能进行血清转化可能会增加ICPs中的突破性HepA风险.
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