相关实验视频
Updated: Jan 14, 2026

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Tissue Engineering of the Intestine in a Murine Model
Published on: December 1, 2012
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在老鼠和猪中提高了宏分子的生物可用性,使用在位形成合成上皮质内膜
Maria Kanelli1, Anthony C Yu1, Derrian Susilo1
1Syntis Bio, 135 Morrissey Blvd, Boston, MA 02125, USA.
概括
这种新型的口腔粘膜上皮质吸收增强剂 (PERMEATE) 系统显著增强了口服大分子的输送. 这一创新平台提高了药物吸收和生物可用性,为改进的口服疗法铺平了道路.
科学领域:
- 生物技术是生物技术.
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
背景情况:
- 由于酶降解和吸收不良,口服大分子的输送具有挑战性.
- 现有的透增强剂 (PE) 提供了有限的改善,需要高剂量.
- 口腔粘膜上皮质吸收增强剂 (PERMEATE) 系统是为了克服这些局限性而开发的.
研究的目的:
- 开发和评估PERMEATE系统,以提高巨分子的口服生物利用性.
- 评估PERMEATE与特定透增强剂 (PE) 和合成组织层 (SYNTTM) 技术相结合的疗效.
- 为了研究PERMEATE在改善口服塞马格卢提德 (SEMA) 的潜力.
主要方法:
- PERMEATE系统使用合成组织层 (SYNTTM) 技术进行现场聚多巴胺涂层.
- 高通量选确定了甘醇酸 (GCA) 和碳酸 (NHCO) 作为有效的PE.
- 在老鼠和猪身上进行了ex vivo和in vivo研究,以评估生物可用性.
主要成果:
- 与单独的SEMA相比,PERMEATE在老鼠中显示了西马 (SEMA) 的生物可用性增加了200倍.
- 在大鼠中,与没有SYNT的SEMA+PE相比,生物可用性增加了6倍.
- 在猪中,PERMEATE实现了2.4%的绝对生物利用率,比对照组提高了6倍.
结论:
- PERMEATE系统显示出在增强口服巨分子递送方面显著的前景.
- 增强的粘膜粘附和长时间的治疗接触是PERMEATE的关键机制.
- PERMEATE支持进一步开发用于口服药物输送中的临床应用.
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