基于连接组的预测模型优化了睡眠,使患有抑郁症的患者与精神健康的对照患者有所区别
Anurima Mummaneni1, Carolyn Amir1, Nicholas B Allen2
1Department of Psychology, University of California, Los Angeles, Los Angeles, California; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California.
Biological psychiatry. Cognitive neuroscience and neuroimaging
|October 18, 2025
概括
预测睡眠持续时间的基于大脑的模型对青少年诊断主要抑郁症 (MDD) 是有前途的. 这些模型确定了与抑郁症相关的大脑连接的差异,这表明了共同的神经支.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 计算生物学 计算生物学
背景情况:
- 基于大脑的预测模型用于使用睡眠特征诊断主要抑郁症 (MDD) 的实用性仍然不清楚.
- 青少年大脑发育及其与精神健康障碍的关系是积极研究的领域.
研究的目的:
- 调查在青少年大脑成像数据上训练的基于连接组的预测模型 (CPM) 是否可以预测睡眠时间并帮助临床诊断MDD.
- 通过检查与睡眠预测相关的功能连接模式来探索MDD的神经相关物.
主要方法:
- 一个基于连接组的预测模型 (CPM) 通过休息状态功能磁共振成像 (rs-fMRI) 数据从青少年大脑认知发展 (ABCD) 研究训练.
- 该CPM利用来自2349名青少年 (11-12岁) 的35,778个双向大脑连接来预测睡眠时间.
- 模型的性能在78名青少年 (14-18岁) 的独立队列中得到验证,包括患有MDD的参与者和对照者,将预测的睡眠时间与自我报告的措施和诊断状态进行比较.
主要成果:
- 在患有MDD的青少年中,CPM成功预测了自我报告的睡眠时间 (部分r = 0.332,p = .009).
- 尽管两组之间自报告的睡眠时间没有显著差异,但CPM准确地区分了患有MDD的青少年和对照群 (部分r = 0.334,p < .001).
- CPM预测的睡眠时间与抑郁症症状严重程度相关 (部分r = 0.294,p < .001),由静止状态网络的低连接性驱动.
结论:
- 被训练来预测客观睡眠时间的CPM对于青少年群体来说是强大的和可概括的.
- 患有MDD的青少年的内在功能连接性差异可以通过优化用于睡眠预测的CPM来检测.
- 这些发现突出了睡眠健康和抑郁症之间共同的神经基础,表明CPM是理解和诊断MDD的潜在工具.
更多相关视频
05:19Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
Published on: July 7, 2023
3.2K
06:23A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
Published on: September 22, 2020
6.0K
相关概念视频
Substance Use Disorders Affecting Sleep
398
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
398
REM Sleep Behavior Disorder
1.4K
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
1.4K
