系统性审查与口服暴露相关的心脏毒性
Heather R Schaefer1, Brenna M Flannery1, Abdul Ibrahim2
1US Food and Drug Administration, Human Foods Program, College Park, MD, USA.
概括
目前美国食品和药物管理局 (FDA) 对口服 (Cd) 的毒理参考值 (TRV) 充分保护免受心血管影响. 这一发现是基于对动物和人类健康研究的系统审查.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 心血管科学 心血管科学
背景情况:
- 美国食品和药物管理局 (FDA) 根据骨和脏毒性建立了口服 (Cd) 毒理参考值 (TRV).
- 新出现的证据表明,Cd暴露也可能影响心血管系统.
研究的目的:
- 系统地审查现有文献,以确定当前的FDA口服Cd TRV范围 (0.21-0.36μg/kg bw/day) 是否可以预防心血管事件.
- 评估与Cd暴露相关的潜在心血管风险.
主要方法:
- 进行了系统的文献审查,选了1354个参考文献,并对123份手稿进行了全文审查.
- 分析了82项研究的数据,包括2022年FDA审查的数据.
- 应用了包含和排除标准来完善研究选择.
主要成果:
- 动物研究表明,暴露在饮用水中的Cd度为1-5 mg/L的老鼠的血压升高.
- 流行病学数据提供了适度的证据,将CD暴露与动脉样硬化,心肌梗塞,心血管死亡率和高血压联系起来.
- 与这些心血管影响相关的报告Cd水平 (血液/尿液中的≥0.5μg/g肌素) 与当前TRV使用的起点一致.
结论:
- 目前的FDA口服Cd TRV范围为0.21-0.36μg/kg bw/day,被认为是对心血管健康的保护.
- 建立的TRV基于和骨毒性,也可以防止不良心血管结果.
- 进一步的研究支持当前Cd暴露指南对于预防心血管疾病的充分性.
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