相关实验视频

Updated: Jan 14, 2026

Using Reference Reagents to Confirm Robustness of Cytokine Release Assays for the Prediction of Monoclonal Antibody Safety

Using Reference Reagents to Confirm Robustness of Cytokine Release Assays for the Prediction of Monoclonal Antibody Safety

Published on: September 15, 2023

在全国范围内缺乏Rh免疫球蛋白时对Rh免疫球蛋白的使用进行了一项调查

Kerry O'Brien¹, Elizabeth Abels², Sara Bakhtary³

¹Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

|October 19, 2025

概括

2023年的Rh免疫球蛋白 (RhIG) 短缺影响了许多美国机构,大多数都遇到了供应问题. 尽管存在短缺,但RhIG仍在产科护理之外使用,这凸显了需要更好地管理资源,以预防胎儿和新生儿 (HDFN) 的血液溶解性疾病.

科学领域:

输血医学输血医学
免疫学免疫学免疫学
产科产科产科产科产科

背景情况:

Rh 免疫球蛋白 (RhIG) 对于预防 D 分免疫和胎儿和新生儿 (HDFN) 溶血性疾病至关重要.
RhIG的使用扩大到包括D-不兼容输血后的免疫预防.
美国在2023年开始出现显著的RhIG短缺.

研究的目的:

在2023年短缺期间评估RhIG使用模式.
了解输血服务如何管理RhIG供应.
确定与 RhIG 可用性相关的挑战和策略.

主要方法:

一项调查通过电子方式分发给AABB认可的机构.
调查答复被计数,并计算频率.
自由文本评论被分类,以分析 RhIG 使用和管理策略.

主要成果:

收到了112个回复,其中70%的人经历了RhIG短缺.
对RhIG的主要适应症是D阴性孕妇,D阳性胎儿/新生儿.
机构实施了库存监控,制造商变更和设施间再分配等策略.
尽管缺乏,但 RhIG 在非产科患者中继续使用.

结论:

大多数受访机构受到RhIG短缺的影响.
输血服务部门继续为非产科指示提供RhIG.
需要更有效地管理 RhIG 的利用,以确保足够的供应以防止抗D HDFN.

关键词:

Rh 免疫球蛋白是一种Rh免疫球蛋白.里格里格里格里格里格短缺短缺短缺短缺

更多相关视频

An Optimized Hemagglutination Inhibition HI Assay to Quantify Influenza-specific Antibody Titers

An Optimized Hemagglutination Inhibition HI Assay to Quantify Influenza-specific Antibody Titers

Published on: December 1, 2017

Quantification of Cellular Densities and Antigenic Properties using Magnetic Levitation

Quantification of Cellular Densities and Antigenic Properties using Magnetic Levitation

Published on: May 17, 2021

相关概念视频

Rh Blood Group

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.

Blood Transfusion and Agglutination

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...

Humoral Immune Responses

Humoral Immune Responses