在接受放射治疗治疗乳腺癌的妇女中评估肺功能. 一个全面的系统审查和元分析
N Daga-Guijarro1, N S Diciolla2, M J Yuste-Sánchez3
1Physiotherapy in Women's Health Research Group - FPSM, Department of Nursing and Physiotherapy, University of Alcalá, Alcalá de Henares, Madrid, Spain.
乳腺癌的放射治疗可能会对肺功能产生负面影响,导致FEV1,FVC和DLCO在治疗后12个月内显著下降. 加强监测和干预对于受影响的患者至关重要.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 辐射疗法 辐射疗法
背景情况:
- 乳腺癌的放射治疗与5-15%的病例与肺纤维化有关.
- 肺功能受损会降低患者的生活质量.
研究的目的:
- 评估放射治疗对乳腺癌患者肺功能的短期,中期和长期影响.
主要方法:
- 这是一项对22项涉及1042名女性的观察性,实验性和准实验性研究的元分析.
- 在Medline,科学网,Scopus和CENTRAL进行文献搜索,截至2024年10月.
- 使用Cochrane ROBINS-E和GRADE框架评估的偏见风险和证据质量.
主要成果:
- 照射疗法,无论是传统的还是低分离的,导致FEV1%预测,FVC%预测和DLCO%预测在治疗后的1,3,6和12个月显著下降.
- 观察到FEV1,FVC和DLCO的临床相关降低 (≥5%),持续长达12个月.
- 总体证据水平是中等的,在各个研究中存在偏差的风险低至高.
结论:
- 放射治疗可以对乳腺癌患者的肺功能产生负面影响,特别是在没有肺节约技术的情况下.
- 放射后肺功能下降可能持续长达12个月.
- 建议进行进一步的研究和加强患者监测,以及支持性干预.
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