通过米 (Oryza sativa L.) 消费的稀土元素的概率性健康风险评估,使用蒙特卡洛模拟
Zzu-Ying Huang1, Chien-Hui Syu2, Lin-Chu Chien3
1Department of Agricultural Chemistry, National Taiwan University, Taipei 10617, Taiwan.
Food chemistry
|October 19, 2025
概括
消费大米会导致接触稀土元素 (REEs). 这项研究发现台湾大米中REEs的非致癌风险很小,儿童因摄入量和体重因素而面临更高的暴露.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 食品安全 食品安全
背景情况:
- 在全球范围内,大米是主要的粮食来源,也是人类接触稀土元素 (REEs) 等环境污染物的重要途径.
- 了解主食中的REE含量对于评估潜在的健康风险至关重要.
- 台湾大米因其在当地饮食中的重要性而被选为本次分析.
研究的目的:
- 量化来自台湾的米样中的15种稀土元素 (REEs) 的度.
- 通过大米消费来评估REEs的饮食暴露和相关的非致癌健康风险.
- 确定影响台湾人口REE暴露的关键因素.
主要方法:
- 对台湾各地采集的265个大米样本进行分析,以确定15个REE的度.
- 应用蒙特卡洛模拟来估计每日摄入量 (EDI) 和评估非致癌风险.
- 进行灵敏度分析以确定导致暴露变化的因素.
主要成果:
- (Ce),兰 (La), (Y) 和 (Nd) 是最丰富的可再生能源,轻型可再生能源占总量的77%.
- 尽管度较低,但重重的REEs导致比例较高的非致癌风险.
- 平均EDI (0.012μg kg−1 bw−1) 和第95百分位EDI (0.043 μg kg−1 bw−1) 大大低于参考值 (70 μg kg−1 bw−1),表明风险低.
- 0-3岁儿童的REE暴露水平最高.
- 摄入率是暴露的主要决定因素,其次是体重和特定REE度 (Y,Ce,Eu,La).
结论:
- 台湾的食中从大米中摄取的REEs目前低于与重大非致癌健康风险相关的水平.
- 幼儿代表了一个脆弱的群体,由于生理因素,需要注意REE暴露.
- 公共卫生策略应考虑摄入率和体重在评估饮食暴露在REEs等环境污染物时.
相关概念视频
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
404
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
404
01:12Relative Risk
2.0K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.0K
01:11Hazard Rate
400
The hazard rate, also known as the hazard function or failure rate, is a statistical measure used to describe the instantaneous rate at which an event occurs, given that the event has not yet happened. From a probabilistic perspective, it represents the likelihood that a subject will experience the event in a very small time interval, conditional on surviving up to the beginning of that interval. In terms of frequency, the hazard rate can be viewed as the ratio of the number of events to the...
400
01:12Hazard Ratio
559
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
For example, in a clinical trial...
559