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光生物调节可以增强老老鼠的认知功能,并调节记忆相关电路中的细胞染色体c氧化酶活性和c-Fos表达

Lucía Rodríguez-Fernández¹, Candela Zorzo¹, Alba Gutiérrez-Menéndez²

¹University of Oviedo, Neuroscience Laboratory, Department of Psychology, Oviedo, Spain; INEUROPA, Instituto de Neurociencias del Principado de Asturias, Oviedo, Spain; ISPA, Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain.

Physiology & behavior

|October 19, 2025

概括

光生物调制疗法改善了中年老鼠的空间记忆和认知灵活性. 这种非侵入性治疗可以增强记忆回路中的大脑活动,而不会影响焦虑或运动功能.

科学领域:

神经科学是一个神经科学.
老年学是指老年学的学科.
生物医学工程生物医学工程

背景情况:

老龄化导致认知能力下降,需要新的治疗干预措施.
光生物调制 (PBM) 疗法提供了一种非侵入性的方法来增强线粒体功能和神经可塑性.
经皮PBM正在探索其减轻与年龄相关的认知缺陷的潜力.

研究的目的:

为了研究中年老鼠中自动化跨皮PBM的行为和神经生物学影响.
评估PBM对认知功能的影响,包括空间记忆和认知灵活性.
检查PBM对神经生物学标记物的影响,如细胞染色体c氧化酶 (CCO) 活性和c-Fos表达.

主要方法:

中年Wistar大鼠每天接受跨PBM (810nm,每天12分钟,持续11天) 针对前额叶皮层.
行为测试评估了类似焦虑的行为,运动活动,空间记忆和认知灵活性.
神经生物学分析包括测量CCO活性和c-Fos表达在边缘和皮层区域.

主要成果:

PBM治疗显著增强了空间记忆和认知灵活性.
没有观察到类似焦虑的行为或运动运动活动的显著变化.
PBM 降低了与记忆相关的大脑区域的 CCO 活性,并增加了背部牙状回形中的 c-Fos 表达.

结论:

自动化跨皮PBM有效调节中年老鼠记忆电路中的认知表现和大脑活动.
预后肌肉管理显示出作为治疗与年龄相关的认知衰退的治疗策略的潜力.
需要进一步的研究来优化参数,评估长期影响,并探索性别特异性反应.

关键词:

衰老的衰老衰老的衰老认知灵活性认知灵活性细胞染色体c氧化酶的作用摄影生物调制 (Photobiomodulation) 是一种生物调制方法.空间记忆是一种空间记忆.c-的使用.

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