在跨诊断性强迫症中,受损的目标导向规划是由对学习任务结构的不确定性解释的
Sirichat Sookud1, Ingrid Martin2, Claire M Gillan3
1Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
强迫性较高的个体由于内部世界模型的不确定性而表现出受损的目标导向决策. 这种与强迫性症状相关的不确定性可能代表特征级别的脆弱性.
科学领域:
- 认知神经科学 认知神经科学
- 计算精神病学是一种计算精神病学.
背景情况:
- 强迫症的特点是减少了以目标为导向的决策和增加了习惯性行为.
- 内部世界建模中这种损害的根本原因尚不清楚.
研究的目的:
- 调查内部世界模型中的不确定性是否有助于强迫性的目标导向决策受损.
- 描述个人如何构建内部模型并量化个人差异.
主要方法:
- 调整了一个游戏化的决策任务,以评估内部模型的形成.
- 采用计算建模来分析行为和个人差异.
- 从两个大样本 (N=551,N=1322) 和纵向数据 (2周,3个月,1年) 收集的数据.
主要成果:
- 较高的强迫性和侵入性思维与较慢的学习和较不确定的环境表现相关.
- 内部模型中的不确定性调解了强迫症状和减少目标导向行为的关系.
- 决策行为在3个月和1年内表现出相对稳定.
结论:
- 强迫性的减少目标导向行为源于不那么确定的内部世界模型.
- 这种不确定性可能代表着对强迫症症状的稳定性,特征级别的脆弱性.
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