诱导渴望和治疗反应在跨脑磁性刺激的烟草使用障碍
Dhvani D Mehta1, Matthew E Sloan2, Alexandra Sas1
1Addictions Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Biological psychiatry. Cognitive neuroscience and neuroimaging
|October 19, 2025
概括
渴望诱导可靠地增加了在烟草使用障碍的重复性跨磁刺激 (rTMS) 期间的渴望. 然而,这种渴望增加并不能预测戒烟成功,这表明这种方法的临床效用有限.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 成 药物 药物 药物 药物
背景情况:
- 重复性横磁刺激 (rTMS) 是一种新兴的心理健康状况治疗方法,包括物质使用障碍.
- 在rTMS被假设通过激活与疾病相关的神经回路来增强治疗效果之前,引起症状,例如诱导渴望.
- 在rTMS治疗成,特别是烟草使用障碍 (TUD) 之前诱导渴望的临床实用性需要进一步研究.
研究的目的:
- 评估诱导渴望是否提高了TUD患者接受深度跨脑磁刺激 (DTMS) 的治疗结果.
- 分析DTMS对TUD的关键多站点试验的数据,以确定诱导渴望对戒断率的影响.
主要方法:
- 262名参与者被随机分配到活跃或虚假的DTMS6周,在前2周内设定戒烟日期.
- 在18个会议中,诱导前后使用视觉模拟尺度测量了渴望.
- 混合效应模型被用来测试诱导渴望是否增加了渴望,以及它的大小是否预测了4周连续戒烟率 (4W-CQR).
主要成果:
- 诱导渴望导致渴望的小但显著增加,没有证据表明跨会话的习惯.
- 提示诱导后渴望的变化没有显著预测试验结束的4W-CQR.
- 在渴望诱导和研究臂 (活跃与假装DTMS) 之间没有发现显著的相互作用.
结论:
- 诱导渴望可靠地增加了DTMS接受DTMS的TUD参与者的渴望.
- 在试验结束时,提示诱导的渴望的程度与戒烟成功无关.
- 需要进一步的研究来探索rTMS在TUD中的机制及其对大脑状态和抑制控制的影响.
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