孕产妇感染 - - 但不是炎症 - - 与儿童时期注意力缺陷/多动性障碍症状有关:基于人口的队列研究
Milan Zarchev1, Frederieke A J Gigase2, Lot de Witte3
1Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, Rotterdam, the Netherlands; Department of Psychiatry, Erasmus MC, Rotterdam, the Netherlands; The Generation R Study Group, Erasmus MC, Rotterdam, the Netherlands.
怀孕期间母亲发烧与后代多动症症状的小幅增加有关. 然而,慢性炎症的标志物,如细胞因子和CRP,与儿童的ADHD风险没有关联.
科学领域:
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
- 免疫学 免疫学 免疫学
背景情况:
- 产前暴露于感染和炎症是注意力缺陷多动症障碍 (ADHD) 的疑似危险因素.
- 关于这种联系的现有研究是不确定的,需要进一步调查.
研究的目的:
- 调查产前暴露于母细胞因子,C-反应蛋白 (CRP) 和发烧与后代患ADHD风险之间的关系.
- 检查多基因分数和母亲压力对这些关联的潜在缓和效应.
主要方法:
- 针对6555对母婴对 (R世代) 进行了前性队列研究.
- 数据包括自我报告的母体发烧/感染,复合细胞因子指数 (IL-1β,IL-6,IL-17a,IL-23,IFN-γ),CRP和ADHD症状 (父母/教师在6,10,14岁时报告).
- 线性混合模型被用于分析,调整了多个母婴因素.
主要成果:
- 在怀孕期间母亲发烧和子女多动症症状增加之间发现了显著的,尽管很小的联系 (ß=0.06).
- 在复合细胞因子指数,单个细胞因子,CRP和ADHD症状之间没有观察到显著的关联.
- 对于神经发育障碍或母亲的压力,暴露和多基因评分之间没有发现显著的相互作用.
结论:
- 怀孕期间的产妇发烧与后代的ADHD症状有关,尽管效果大小适度.
- 慢性炎症的标志物,如细胞因子和CRP在这个队列中与ADHD风险无关.
- 这些发现有助于理解ADHD的围产期风险因素.
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