单细胞计数与血清阳性类风湿性关节炎相关间歇性肺病的临床结果的相关性:一个病例控制研究
Taehun Kim1, Jung Hee Hong2, Seong Hwan Youn1
1Division of Pulmonary Medicine, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea.
Respiratory medicine
|October 19, 2025
概括
高血单细胞计数可能表明血清阳性类风湿性关节炎 (SPRA) 患者的间歇性肺病 (ILD). 然而,单细胞水平并不能独立预测SPRA相关的ILD队列中的存活率.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
背景情况:
- 血单细胞计数升高与间歇性肺病 (ILD) 患者的生存率降低有关,包括异常性肺纤维化 (IPF).
- 研究了血单细胞计数与血清阳性类风湿性关节炎 (SPRA) 患者的ILD之间的关联.
研究的目的:
- 为了确定血单细胞计数是否与SPRA患者的ILD存在有关.
- 为了评估单细胞计数的预后价值,以评估SPRA患者的存活率.
主要方法:
- 追溯分析295名SPRA患者的基线胸部CT扫描.
- 根据CT发现,患者被分为ILD和非ILD组.
- 分析了单细胞计数,类风湿性因子 (RF) 和抗周期性素化 (anti-CCP) 水平.
主要成果:
- 与非ILD组相比,ILD组 (30.8%) 的单细胞数量显著增加.
- 在调整年龄和性别后,较高的单细胞计数与ILD有关.
- 群体之间RF和抗CCP水平没有显著差异;ILD与更差的存活率相关,但单细胞计数不是独立的预后因素.
结论:
- 在SPRA患者中,较高的单细胞计数可能与ILD的存在有关.
- 风湿因子和抗CCP水平在这个队列中没有发现与ILD或生存有关.
- 单细胞计数不是SPRA相关ILD生存的独立预测指标.
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