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在患有轻度至中度慢性病的成年人中恶化心力衰竭事件
Linda Ye1, Michael P Girouard2, Alan S Go3
1Department of Medicine, Kaiser Permanente San Francisco Medical Center, San Francisco, CA.
American heart journal
|October 19, 2025
概括
恶化心力衰竭 (WHF) 在患有轻度至中度慢性病 (CKD) 的成年人中很常见. 观察到较高的事件率与较低的估计膜过率 (eGFR) 和较大的白膜尿,突出显示了对心脏保护疗法的需要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 慢性病 (CKD) 是心力衰竭 (HF) 的重要危险因素.
- 在轻度至中度慢性病患者中,恶化心力衰竭 (WHF) 事件的具体负担仍然不够描述.
研究的目的:
- 为了评估WHF事件的发生率和负担,在当代成年人群中诊断出轻度至中度的CKD.
主要方法:
- 在2012年至2021年间,确定了一组患有轻度至中度CKD的成年人 (eGFR 30-59毫升/分钟/1.73m2或eGFR ≥60毫升/分钟/1.73m2与白色素尿).
- 结果包括住院,急诊室访问和WHF的门诊接触.
- 数据根据先前的心力衰竭状态和CKD严重程度进行了分层.
主要成果:
- 该研究包括375,495名患有轻度至中度CKD的成年人.
- 累计WHF事件的发生率为每100人/年2.42,住院是最常见的 (1.85每100人/年).
- WHF事件发生率显著增加,估计的淋巴细胞过率 (eGFR) 较低,白尿水平较高.
结论:
- 恶化的心力衰竭是患有慢性脏病早期阶段的成年人患病的重要来源.
- 低EGFR和白蛋白尿增加的个体面临着特别高的WHF事件风险.
- 这些发现强调了在这种高风险人群中实施心脏保护和脏保护策略的必要性.
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