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对神经母细胞瘤ALK遗传变异报告的协调:一项SIOPEN生物学研究

Alexandra Saint-Charles1, Julien Masliah-Planchon2, Elnaz Saberi-Ansari1

  • 1INSERM U1330, Children's Oncology Research Unit, Research Center, PSL Research University, Institut Curie, Paris, France; SIRIC Laboratory of Translational Research in Pediatric Oncology, Translational Research Department, Research Center, PSL Research University, Paris, France.

The Journal of molecular diagnostics : JMD
|October 19, 2025
PubMed
概括

在高风险神经母细胞瘤中,精确的ALK遗传检测对于临床决策至关重要. 协调分子技术和报告可确保ALK向治疗的可靠诊断.

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...