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作为抗癌候选人的蛇毒衍生:开创下一代疗法
José R Almeida1, Edgar A Pinos-Tamayo2, Bruno Mendes3
1School of Pharmacy, University of Reading, Reading RG6 6UB, UK; Biomolecules Discovery Group, Universidad Regional Amazónica Ikiam, Tena 150150, Ecuador.
蛇毒对新型癌症治疗有前途,具有强大的抗癌活性. 克服先进技术的翻译挑战是开发这些创新的治疗方法的关键.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 药物发现 药物发现 药物发现
背景情况:
- 传统的癌症治疗面临诸多挑战,包括副作用,可访问性和成本.
- 由于不完全治愈率和治疗负担,新的治疗策略至关重要.
- 基于的疗法正在成为癌症治疗的有希望的替代方案.
研究的目的:
- 审查以蛇毒为灵感的类作为创新抗癌剂设计的模板.
- 探索蛇毒作为癌症药物发现的生物活性成分来源的潜力.
- 讨论将毒素衍生的潜在转化为临床治疗的策略.
主要方法:
- 对传统的癌症治疗和基于的治疗方法的审查.
- 蛇毒作为生物活性成分库的分析.
- 在 silico 方法中研究毒素启发的结构,生物化学和生物活性.
- 检查翻译方面的挑战和提出的解决方案.
主要成果:
- 识别了30多种来自蛇毒的,具有针对各种癌细胞的微分子解活性.
- 证明了以毒素为灵感的类作为抗癌剂的潜力.
- 突出了体外疗效与临床转化之间的差距.
结论:
- 蛇毒衍生的酸是药物发现的宝贵支架,具有历史上的好处.
- 需要多学科的努力来克服基于毒素的癌症治疗方法的发展障碍.
- 像人工智能和基工程这样的先进技术可以促进下一代基于毒的癌症治疗方法的开发.
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