母体血清金属混合物与不良分娩结果之间的关联:一个前性队列研究
Luodan Zhang1, Fa Zeng2, WenZhu3
1Department of Pediatric Nephrology, Anhui Provincial Children's Hospital, Children's Hospital of Anhui Medical University, Hefei 230000, Anhui, China; The Fifth Clinical Medicine College, Anhui Medical University, Hefei 230032, Anhui, China.
Toxicology and applied pharmacology
|October 19, 2025
概括
孕妇在怀孕期间接触重金属混合物与不良分娩结果有关. 联合金属暴露与早产风险增加有关,但降低了先天性异常和LGA.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 儿科健康 儿科健康
背景情况:
- 孕产妇接触重金属是一种已知的产后不良结果的危险因素.
- 怀孕期间多次金属暴露的综合影响尚不清楚.
研究的目的:
- 调查怀孕中期血清金属混合物与各种不良分娩结果之间的联系.
- 确定有助于这些关联的特定金属.
主要方法:
- 对429对母婴婴儿进行前性队列研究.
- 血清金属含量 (Fe,Se,Rb,Tl,Sb,I) 量化使用ICP-MS.
- 用于分析混合物效应的贝叶斯核机器回归 (BKMR) 和加权量子素和 (WQS) 回归.
主要成果:
- 联合金属暴露与早产 (PTB) 有积极的关联,与先天性异常和LGA.负相关.
- (Tl) 和铁 (Fe) 显示出与PTB的负相关性,而 (Se), (Sb) 和 (I) 显示出与PTB的正相关性.
- WQS回归证实了与PTB的积极关联 (β=1.366) 和与LGA的负相关 (β=-2.224).
结论:
- 产前暴露于金属混合物对出生结果有复杂的影响.
- 研究结果强调需要有针对性的预防策略,以保护母亲和胎儿的健康免受元素混合物的风险.
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