早期食品引入的指南和食物过敏的模式
Stanislaw J Gabryszewski1,2,3, Jesse Dudley2, Jennifer A Faerber2
1Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Pediatrics
|October 19, 2025
概括
对于花生过敏的早期引入指南似乎有效,显著降低了儿童免疫球蛋白E介导食物过敏 (IgE-FA) 的发生率. 这些发现支持公共卫生建议对过敏预防的影响.
科学领域:
- 儿科过敏和免疫学
- 公共卫生建议 公共卫生建议
- 食物过敏预防 预防食物过敏
背景情况:
- 免疫球蛋白E介导的食物过敏 (IgE-FA) 是儿科日益关注的问题.
- 早期引入花生指南的出版旨在缓解花生过敏的增加.
- 了解这些指南对过敏率的影响对于公共卫生战略至关重要.
研究的目的:
- 在发布早期引入指南后,评估花生 (或任何) IgE-FA 诊断率的变化.
- 评估最初指南和随后的补充指南对IgE-FA发病率的影响.
- 确定这些公共卫生建议是否影响了幼儿食物过敏的流行程度.
主要方法:
- 利用来自美国儿科学会CER2网络的电子健康记录数据.
- 根据时间段定义的队列:指导方针前,指导方针后和附加指导方针后.
- 使用后勤回归,考克斯比例危险建模和中断时间序列分析来比较诊断率.
主要成果:
- 观察到花生IgE-FA和任何IgE-FA后指南和后附录指南的累积发病率和风险的显著下降.
- 危险比率表明,在初始指南之后,发展花生IgE-FA (HR,0.65) 和任何IgE-FA (HR,0.69) 的风险降低了.
- 在补充后的指南中还注意到了进一步显著的减少 (花生IgE-FA的HR为0.55;任何IgE-FA的HR为0.63).
结论:
- 在实施早期引入指南后,花生或任何IgE-FA诊断的发生率显著下降.
- 研究结果支持这些具有里程碑意义的公共卫生建议在减少食物过敏发病率方面的有效性.
- 这些结果强调了基于证据的指导方针在儿科过敏管理中的重要性.
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