Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Protein-protein Interfaces02:04

Protein-protein Interfaces

14.4K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
14.4K
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

4.4K
4.4K
Protein Networks02:26

Protein Networks

4.5K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.5K
Protein Networks02:26

Protein Networks

2.8K
2.8K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

7.2K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.2K
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

2.1K
2.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Loss of O-GlcNAcylation in cardiac myocytes triggers the integrated stress response, contributing to heart failure.

The Journal of biological chemistry·2025
Same author

Enhanced kinase translocation reporters for simultaneous real-time measurement of PKA, ERK, and calcium.

The Journal of biological chemistry·2025
Same author

Enhanced kinase translocation reporters for simultaneous real-time measurement of PKA, ERK, and Ca<sup>2</sup>.

bioRxiv : the preprint server for biology·2024
Same author

The multifaceted role of intracellular glycosylation in cytoprotection and heart disease.

The Journal of biological chemistry·2024
Same author

Second international symposium on the chaperone code, 2023.

Cell stress & chaperones·2024
Same author

Cardioprotective O-GlcNAc signaling is elevated in murine female hearts via enhanced O-GlcNAc transferase activity.

The Journal of biological chemistry·2023

相关实验视频

Updated: Jan 14, 2026

Mapping Dysfunctional Protein-Protein Interactions in Disease
09:39

Mapping Dysfunctional Protein-Protein Interactions in Disease

Published on: October 24, 2025

558

OGT的内部圈子:蛋白质相互作用和功能影响.

Fiddia Zahra1, Natasha E Zachara2

  • 1The Department of Biophysics and Biophysical Chemistry at the Johns Hopkins University School of Medicine, Baltimore, MD, 21202, USA; The Graduate Program in Biological Chemistry, at the Johns Hopkins University School of Medicine, Baltimore, MD, 21202, USA.

Advances in biological regulation
|October 19, 2025
PubMed
概括

与O相关的β-N-乙糖胺 (O-GlcNAc) 是一种影响许多细胞过程的关键蛋白质修饰. 了解O-GlcNAc转移酶 (OGT) 如何通过其相互作用体实现广泛的基质特异性,是解读其在健康和疾病中的作用的关键.

关键词:
葡萄糖基酶化是什么? 葡萄糖基酶化互动组互动组是一个互动组.细胞内细胞内细胞内.这就是O-GLcNAcc.在O-GlcNAc转移酶.信号传输 信号传输在UDP-GlcNAc中使用.

更多相关视频

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
07:57

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation

Published on: August 21, 2019

9.1K
Transmembrane Domain Oligomerization Propensity determined by ToxR Assay
06:45

Transmembrane Domain Oligomerization Propensity determined by ToxR Assay

Published on: May 26, 2011

15.6K

相关实验视频

Last Updated: Jan 14, 2026

Mapping Dysfunctional Protein-Protein Interactions in Disease
09:39

Mapping Dysfunctional Protein-Protein Interactions in Disease

Published on: October 24, 2025

558
Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
07:57

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation

Published on: August 21, 2019

9.1K
Transmembrane Domain Oligomerization Propensity determined by ToxR Assay
06:45

Transmembrane Domain Oligomerization Propensity determined by ToxR Assay

Published on: May 26, 2011

15.6K

科学领域:

  • 生物化学 生化学
  • 分子生物学分子生物学
  • 细胞生物学 细胞生物学

背景情况:

  • 与O相关的β-N-乙糖胺 (O-GlcNAc) 是哺乳动物中一个重要的翻译后修饰,它修饰了5000多种蛋白质.
  • O-GlcNAcylation影响关键的细胞功能,包括信号传导,表观遗传学,转录,翻译和生物能量学.
  • O-GlcNAc的失调与代谢障碍,癌症,神经退行症和心力衰竭等疾病有关.

研究的目的:

  • 探索O-GlcNAc转移酶 (OGT) 广泛基质特异性的基础机制.
  • 审查介导OGT局部化,活性和基质选择性的多样化的蛋白质合作伙伴网络.
  • 调查OGT监管中翻译后修改和基质可用性的作用.

主要方法:

  • 关于OGT交互器及其功能作用的文献综述.
  • 对研究OGT调节和基质特异性的研究进行分析.
  • 讨论蛋白质伙伴对OGT功能的影响.

主要成果:

  • 建议通过与多样化的蛋白质合作伙伴网络的相互作用来调解OGT的功能多功能性.
  • 这些相互作用体作为适配器,支架或基板,影响OGT的定位,活动和基板选择性.
  • 翻译后的修改和基质的可用性是OGT监管和特异性的重要因素.

结论:

  • 了解OGT相互作用体对于阐明其在各种细胞过程和疾病中的作用至关重要.
  • 围绕OGT的复杂监管网络有助于其广泛的基质特异性.
  • 对OGT调节及其相互作用的进一步研究为O-GlcNAc相关疾病提供了治疗潜力.