高剂量甲状腺素治疗的全面评估:一项追溯观察性试验
Hadeer Ehab Barakat1, Kholood Ashraf El Bahy2, Sandy Victor Labib2
1Ahram Canadian University, Giza, Egypt. hadeer.ehab7785@gmail.com.
Journal of the Egyptian National Cancer Institute
|October 19, 2025
概括
在接受高剂量MTX (HDMTX) 的癌症患者中预测毒性,监测48小时血清甲基酸盐 (MTX) 水平至关重要. 升高的水平与不良结果相关,如增加抗微生物药物的使用和住院时间.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 临床毒理学 临床毒理学
背景情况:
- 高剂量甲基酸盐 (HDMTX) 用于化疗和免疫抑制.
- HDMTX (≥500 mg/m2) 可能导致严重的毒性和肝毒性.
- 了解48小时MTX水平是管理毒性风险的关键.
研究的目的:
- 评估癌症患者48小时血清MTX水平的预测因素.
- 评估与HDMTX相关的毒性概况,重点关注毒性和肝毒性.
- 检查MTX水平,住院时间 (LOS),抗菌素使用和死亡率之间的关系.
主要方法:
- 开罗大学国家癌症研究所的回顾性队列研究 (2022年1月至2024年12月).
- 包括接受HDMTX治疗癌症的患者.
- 收集有关人口统计,MTX剂量,48小时MTX水平,病史,抗菌剂和不良影响的数据.
主要成果:
- 48小时升高的MTX水平 (≥1.28μmol/L) 与肺溢液,淋巴瘤诊断和抗菌药物的使用增加有关.
- HDMTX与卡巴,万科米辛和诺基诺使用有关.
- 在HDMTX和急性损伤 (AKI) 或LOS之间没有发现显著的关联;肝毒性在骨肉瘤患者中更常见.
结论:
- 48小时血清MTX水平是毒性的重要指标.
- 监测MTX水平有助于预测住院时间,抗菌药物需求和死亡风险.
- 密切监测HDMTX水平对于减轻治疗并发症至关重要.
更多相关视频
04:04Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
10.9K
08:12Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
Published on: March 14, 2019
5.9K
相关概念视频
01:29Therapeutic Drug Monitoring: Affecting Factors
200
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
200
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
483
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
483
01:26Therapeutic Drug Monitoring: Drug Analysis Methods
176
Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
176
02:56Treatment Resistant Cancers
3.7K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.7K