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Updated: Jan 14, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
07:23

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

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在雄性小鼠的脊柱GABAergic内神经元中通过EZH2-介导的Trpc5抑制来降低吗啡耐受性

Li Wan1,2, Mengyao Zhang1, Haiyue Guo1

  • 1Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, 211166, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|October 20, 2025
PubMed
概括

重复使用吗啡会减少TRPC5通道,损害疼痛缓解. 激活TRPC5通道与riluzole或基因疗法可以恢复吗啡.

关键词:
在 EZH2 中使用.有GABA的内部神经元.吗啡耐受性 吗啡耐受性TRPC5 TRPC5 需要一个人.

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