相关实验视频

Updated: Jan 14, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Published on: June 23, 2019

创新的绿色合成和多功能应用的pyrimidopyrimidine衍生物

Ruchi Bharti¹, Ankita Thakral¹, Ajay Thakur¹

¹Department of Chemistry, University Institute of Sciences, Chandigarh University, Mohali, Punjab, 140413, India.

Current organic synthesis

|October 20, 2025

概括

这项研究提出了使用酸的pyrimidopyrimidines和amino-dimethylpyrimidines的环保合成. 化合物4i显示出强大的抗氧化和抗微生物活性,突出其治疗潜力.

科学领域:

绿色化学绿色化学
药用化学医学化学
计算化学的计算化学

背景情况:

引入了一个环保的,单多元组件合成的pyrimidopyrimidines和amino-1,3-dimethylpyrimidines.
使用水性介质和酸作为可持续合成的催化剂.

研究的目的:

建立对异环化合物的可持续合成方法.
评估生物活动,包括抗氧化,抗菌和抗真菌的特性.
用计算方法研究分子结构和电子性质.

主要方法:

合成的皮里米多皮里米丁 (4a-4i) 和氨基-1,3-二甲基皮里米丁 (5a-5d).
使用元素分析,IR和NMR光谱学来表征化合物.
通过DPPH,TAC和ABTS测定来评估抗氧化活性.
进行了密度函数理论 (DFT) 计算,用于结构和电子分析.
进行了抗菌和抗真菌检测.

主要成果:

化合物4i表现出显著的抗氧化活性 (99.13%的DPPH抑制) 和强大的抗菌作用.
化合物5b显示出最高的ABTS活性 (100%).
DFT分析证实了分子结构和反应性,4c化合物是最稳定的,4i基于能量频段间隙最具反应性.
化合物4i表现出针对格兰美阳性和格兰负性细菌以及Candida albicans的广泛活性.

结论:

合成的pyrimidopyrimidine和amino-dimethylpyrimidine衍生物显示出对治疗应用的希望.
该研究推进了对生物活性异环化合物的环保合成方法.
突出了化合物4i作为进一步药物开发的主要候选物的潜力.

关键词:

绿色合成是一种绿色合成.它具有抗菌活性,具有抗菌活性.抗真菌研究研究的研究.抗氧化剂测试. 抗氧化剂测试.密度函数理论密度函数理论皮尔米多皮里米丁的衍生物.

更多相关视频

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach

Published on: June 10, 2021

Author Spotlight: Advancing Antimicrobial Resistance Research with Innovative Approaches and Synthetic Compounds

Author Spotlight: Advancing Antimicrobial Resistance Research with Innovative Approaches and Synthetic Compounds

Published on: September 27, 2024

相关概念视频

Biosynthesis of Nucleic Acids

Biosynthesis of Nucleic Acids

Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...

Aryldiazonium Salts to Azo Dyes: Diazo Coupling

Aryldiazonium Salts to Azo Dyes: Diazo Coupling

The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the para...

Cycloaddition Reactions: Overview

Cycloaddition Reactions: Overview

Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.