在治疗动脉样硬化时,植物性天然产品针对炎症
Zhen Hua1, Xiaojie Wang2, Le-Le Qin3
1Department of Cardiology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Frontiers in pharmacology
|October 20, 2025
概括
植物性天然产品通过向炎症,为抗动脉样硬化 (AS) 药物提供了一个有希望的来源. 关键化合物,如黄类和类,通过NF-κB/NLRP3抑制和ROS清理等途径表现出潜在的作用.
科学领域:
- 药理学和天然产品化学
- 心血管疾病研究研究
- 炎症和免疫学 炎症和免疫学
背景情况:
- 动脉样硬化 (AS) 是一种慢性炎症性血管疾病,是冠心病等潜在疾病的基础.
- 植物性天然产品以其多样化的标和丰富的化学结构而闻名,为新型抗AS药物开发提供了机会.
- 了解炎症和AS之间的相互作用对于确定有效的治疗策略至关重要.
研究的目的:
- 系统地审查针对AS治疗炎症的植物性天然产品.
- 分析有效的抗AS代谢物的化学结构和植物起源.
- 阐明主要的抗炎机制和新兴的治疗途径.
主要方法:
- 对10种植物物种和23种高潜能代谢物的全面分析.
- 关键化学结构的识别,包括黄类,类,沙素和多糖类.
- 审查这些天然产品所针对的主要抗炎途径,例如NF-κB/NLRP3炎症酶抑制和ROS清除.
主要成果:
- 具有抗AS特性的天然产品主要来自阿拉里亚系,乌姆贝利费拉系,法巴系和拉米亚系.
- 黄类,类和素显示出抗AS活性的显著潜力.
- 关键机制包括NF-κB/NLRP3炎症酶抑制,反应性氧物种 (ROS) 清除和内皮保护.
结论:
- 植物性天然产品,特别是黄类,类和沙素,在开发有效的抗AS药物方面具有显著的前景.
- 通过NLRP3炎症酶抑制和肠道微生物群调节等途径向炎症是有希望的治疗方向.
- 对这些天然产品的药理机制的进一步研究将支持临床应用和工业生产,以改善AS治疗并减少副作用.
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