高灵敏度C反应蛋白 (hs-CRP) 作为预测尿路感染 (UTI) 严重程度和相关并发症的生物标志物
Zafar Ahmad Khan1, Ishtiaq Ahmad2, Ashraf3
1Urology, Medical Teaching Institution, Mardan Medical Complex, Mardan, PAK.
Cureus
|October 20, 2025
概括
高敏感性C反应蛋白 (hs-CRP) 水平与尿路感染 (UTI) 的严重程度相关. 升高的hs-CRP表明更严重的尿路感染和潜在的并发症,有助于临床决策.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染性疾病 传染性疾病
- 临床化学 临床化学
背景情况:
- 尿路感染 (UTI) 很普遍,导致严重的发病率和医疗费用.
- 尿路感染的严重程度从不复杂的囊炎到败血症,有可能导致脏痕.
- 高灵敏度C反应蛋白 (hs-CRP) 是一种全身炎症生物标志物,在尿路感染中具有潜在的预后价值.
研究的目的:
- 调查hs-CRP水平与尿路感染严重程度之间的关系.
- 评估hs-CRP与临床因素的关联,如并发症和医院结局.
- 确定hs-CRP作为尿路感染并发症预后工具的潜力.
主要方法:
- 一项对173名尿路感染患者进行的横截面观察研究.
- 将患者分为轻度,中度和重度感染组.
- 使用罗氏科巴斯e411分析仪测量hs-CRP水平;统计分析包括决策树建模.
主要成果:
- 在高hs-CRP水平和尿路感染严重程度 (轻度:15.2 mg/L,中度:21.5 mg/L,严重:26.5 mg/L) 之间发现了显著的关联.
- hs-CRP水平与并发症相关:高血压 (24.8 mg/L),糖尿病 (22.6 mg/L) 和慢性病 (27.34 mg/L).
- 决策树分析确定了预测严重程度和并发症的hs-CRP值;大肠杆菌是最常见的病原体.
结论:
- hs-CRP是评估尿路感染严重程度和预测并发症的可靠生物标志物.
- hs-CRP与严重程度,并发症和结果的相关性支持其临床实用性.
- hs-CRP在治疗尿路感染患者的临床决策中提供帮助.
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