乳清蛋白衍生的抗氧化特性:激素清除和细胞保护作用
Ryota Suzuki1, Sayuri Arai1, Masaki Kurimoto1
1Food Function Research Institute Morinaga Milk Industry Co., Ltd. Kanagawa Japan.
Food science & nutrition
|October 20, 2025
概括
乳清蛋白水解剂产生八种抗氧化,包括新型GYDTQ. 这些在对抗氧化应激和运动疲劳方面表现有前途,DTDYKKY显示出显著的细胞保护作用.
科学领域:
- 生物化学 生物化学
- 食品科学 食品科学 食品科学
- 分子生物学分子生物学
背景情况:
- 乳清蛋白水解剂 (WPH) 含有具有潜在抗氧化特性的.
- 来自WPH的单个序列的特定抗氧化剂贡献尚未得到充分理解.
- 氧化压力与各种健康问题有关,包括运动引起的疲劳.
研究的目的:
- 识别和表征来自WPH的抗氧化.
- 评估这些的激素清除和细胞保护活性.
- 探索WPH衍生的潜力,作为减轻氧化应激的功能性食物.
主要方法:
- 从WPH中分离基于性氧基吸收能力 (H-ORAC) 活动的分离.
- 使用DPPH和ABTS激素清除试验评估抗氧化活性.
- 在过氧化诱导的氧化应激下对C2C12核细胞的细胞保护作用的评估.
主要成果:
- 他们确定了八种抗氧化:GYDTQ,GY,VY,DTDYKKY,WYS,WY,LDQW和YW.
- LDQW具有最高的H-ORAC,YW显示最强的DPPH活动,而WYS显示最高的ABTS活动.
- DTDYKKY,GYDTQ,LDQW和WY显著恢复了细胞活力,DTDYKKY是最有效的;GYDTQ显示出高细胞保护尽管低激素清理.
结论:
- WPH是一种具有不同作用机制的强有力的抗氧化的来源.
- 像DTDYKKY和GYDTQ这样的特定可以显示出对抗氧化应激的显著细胞保护作用.
- WPH及其具有作为预防氧化应激和运动诱导疲劳的功能成分的潜力.
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