结合大气冷等离子体和过氧化治疗在伤口替代品上的抗菌疗效
Praj K Patel1, Preisha Mishra1, Habiba K Ashour1
1Department of Mechanical and Aerospace Engineering, Rutgers University, 98 Brett Road, Piscataway, NJ, 08854, USA.
Biochemistry and biophysics reports
|October 20, 2025
概括
结合冷等离子体 (CP) 和过氧化 (H2O2) 显示在类似伤口的表面上增强了细菌不活化. 这项研究评估了CP和H2O2对组织的疗效,证明了抗菌治疗查的有希望方法.
科学领域:
- 生物医学工程 生物医学工程
- 微生物学 微生物学
- 等离子体物理学的物理学
背景情况:
- 抗菌素耐药性需要新的治疗策略.
- 冷等离子体 (CP) 为细菌无活化提供了一种非热方法.
- 对复杂的伤口替代品的治疗方法的评估至关重要.
研究的目的:
- 评估冷血 (CP) 和过氧化 (H2O2) 对于细菌失活的联合疗效.
- 为了比较在均 () 和不均 (肉组织) 表面上的治疗效果.
- 建立一种查方法,用于伤口替代品的抗微生物治疗.
主要方法:
- 表面介电屏障放电 (SDBD) 冷等离子装置用于处理.
- 埃斯切里希亚大肠杆菌 (E. coli) 的细菌失活,通过阿加和乳腺组织进行评估.
- 单独使用 CP,单独使用 H2O2 和联合使用 CP + H2O2 的治疗方法的比较.
主要成果:
- CP在上降低了大肠杆菌的7日志,但在组织上只降低了0.88日志.
- 3%的H2O2在肉组织上减少了1.06个日志.
- 结合CP + H2O2治疗导致1.69日志减少组织,通过延长治疗时间进一步增强.
结论:
- 与光滑表面相比,在复杂的生物组织上,细菌失活效率较低.
- CP和H2O2的组合显著提高了伤口替代品的抗菌疗效.
- 这种方法为新的伤口感染治疗提供了有价值的临床前查工具.
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