三级淋巴体结构的空间和成熟度异质性塑造了免疫微环境和前列腺癌的进展
Zhongyuan Wang1,2, Qintao Ge1,2, Ren Mo3
1Department of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Journal of the National Cancer Center
|October 20, 2025
概括
前列腺癌 (PCa) 中的三级淋巴体结构 (TLS) 与更好的结果有关. 内TLS,特别是成熟的TLS,表明抗瘤免疫反应更强,患者的生存率更好.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 三级淋巴体结构 (TLS) 是在慢性炎症期间形成的异位淋巴体聚合物.
- 在各种癌症中,TLS显示出作为预后生物标志物和抗瘤免疫力调解者的潜力.
- 人们对TLS在前列腺癌 (PCa) 中的异质性,空间分布,成熟度和预后/免疫学意义的了解很少.
研究的目的:
- 调查TLS在PCa中的异质性.
- 评估瘤微环境 (TME) 中的TLS特征和免疫成分之间的关系.
- 评估TLS异质性在PCa患者的预后影响.
主要方法:
- 免疫组织化学和多谱光免疫组织化学 (mIHC) 用于分析TLS.
- 用空间多组学分析来研究TLS和免疫细胞相互作用.
- 在TCGA和富丹大学上海癌症中心队列的701名PCa患者中评估了预后影响.
- 用CellTreck和deconvolution算法进行细胞局部化和通信分析.
主要成果:
- 在约20%的PCa患者中发现了TLS,内TLS (intra-TLS) 比周周TLS (peri-TLS) 更常见.
- 患有TLS内的患者表现出明显更好的无疾病和无进展生存率.
- 成熟的TLS内部与增加的T效应细胞,干扰素通路激活和增强的抗瘤免疫力有关,尽管PD-L1和调节性T细胞 (Tregs) 减少了.
- 空间多组学揭示了成熟的TLS中丰富的免疫细胞多样性和高内皮静脉 (HEV) 密度,树突细胞和B细胞之间有显著的相互作用.
结论:
- TLS异质性,特别是空间分布和成熟度,与TME激活和PCa中改善的临床结果密切相关.
- 成熟的TLS与强大的抗原呈现和B细胞驱动的免疫反应有关.
- 这些发现为PCa免疫格局提供了洞察力,并支持基于免疫的精确分层和治疗开发.
关键词:
高的内皮静脉静脉 (High endothelial venules) 是一个内皮静脉.前列腺癌是什么意思 前列腺癌是什么意思空间的多态学.三级淋巴状结构的第三级淋巴状结构.瘤微环境是一个微环境.更多相关视频
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