系统性炎症反应指数和中风后之间的相关性基于多重逻辑回归分析
Yong Mei Hu1, Hua Huang2, Yu Ting Chen1
1College of Life and Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Frontiers in neurology
|October 20, 2025
概括
系统性炎症反应指数 (SIRI) 的升高与中风后 (PSE) 的更高风险有关. 这种关联在中风患者中具有先前存在的健康状况时特别强烈,这表明SIRI是潜在的生物标志物.
科学领域:
- 神经学 神经学
- 炎症研究的研究.
- 发现生物标志物的发现.
背景情况:
- 脑卒中后 (PSE) 是影响中风患者结果的重大并发症.
- 系统性炎症反应指数 (SIRI) 是一种新的炎症标志物,但其在PSE中的作用尚不清楚.
研究的目的:
- 调查SIRI水平与中风患者PSE发生之间的相关性.
- 探索SIRI作为PSE早期预警指标的潜力.
主要方法:
- 对226名中风患者的回顾性分析,分为PSE和非PSE组.
- 使用多变量物流回归和受限制立方支线 (RCS) 模型来评估SIRI和PSE之间的关系.
- 进行了分层分析,以评估与人口统计,生活方式,并发症和实验室参数的相互作用.
主要成果:
- 与非PSE组相比,PSE组的患者表现出明显更高的基线SIRI水平 (p < 0.001).
- 在患有潜在疾病的患者中观察到SIRI和PSE之间的显著相互作用 (p < 0.001).
- RCS分析显示,SIRI和PSE风险之间存在非线性正相关性,SIRI=1.36的拐点.
结论:
- 升高的SIRI与增加PSE风险有关,特别是在具有并发症的中风患者中.
- SIRI可以作为一种有价值的炎症生物标志物,用于早期检测和对PSE进行分层管理.
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