口腔微生物群和炎症性肠病:新的理解和呼吁采取行动
Michael Saadeh1, Sydney Donohue1, Shaina Ailawadi1
1Department of Internal Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, United States.
World journal of gastroenterology
|October 20, 2025
概括
口腔微生物群影响全身健康,影响胃肠道和炎症疾病. 新出现的证据强调了它在炎症性肠病等疾病中的作用,需要更新的护理策略.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 口腔微生物群,一个复杂的微生物群体,在健康和疾病中发挥着双重作用.
- 口腔微生物群中的失生症与局部口腔疾病和越来越多的系统性影响有关.
- 口腔微生物群的影响不仅仅是口腔健康,还包括胃肠道和非胃肠道疾病.
研究的目的:
- 审查最新证据,将口腔微生物组与全身性疾病,特别是炎症性肠病 (IBD) 联系起来.
- 探索口腔微生物群影响全身健康的机制.
- 确定优化IBD患者护理的新策略.
主要方法:
- 关于口腔微生物组和全身疾病的最新研究的文献综述.
- 分析机制,包括细胞因子上调,细胞粘附过程和病原体转移.
- 检查口腔微生物组失调和炎症性肠道疾病之间的关联.
主要成果:
- 越来越多的证据支持口腔微生物组与IBD等系统性炎症性疾病之间的因果关系.
- 机制包括细胞因子失调,改变细胞过程和微生物转移.
- 口腔微生物组与诸如巴雷特食道病,脂肪肝病和胃肠道癌症等疾病有关.
结论:
- 口腔微生物组显著影响全身健康和疾病,包括炎症性肠道疾病.
- 了解这些联系对于开发有效的治疗策略至关重要.
- 需要加强临床实践,以应对口腔微生物组失调的系统性影响.
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