全血计衍生炎症标志物与胃之间的关联:一个横截面研究
Qi Shen1, Zhong-Hua Sun2, Ya-Meng Xu3
1Department of Gastroenterology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
World journal of gastroenterology
|October 20, 2025
概括
全血清 (CBC) 衍生的炎症标志物,如全身炎症反应指数 (SIRI),与胃 (GU) 患病率有显著关联. 这些标记可能有助于识别患GU的风险较高的个体.
科学领域:
- 胃肠病学 胃肠病学
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
背景情况:
- 胃 (GU) 是一种常见的胃肠道疾病,受炎症和免疫反应的影响.
- 全血清 (CBC) 衍生的炎症生物标志物为系统性炎症和免疫状态提供了新的见解.
- 从CBC衍生的炎症标志物和GU之间的关联需要进一步调查.
研究的目的:
- 调查CBC衍生的炎症标志物与胃 (GU) 发生之间的关联.
- 评估这些标志物对GU的预测能力.
- 确定关键的炎症指标与GU有显著联系.
主要方法:
- 对纳大学第二附属医院胃肠病科 (2023-2024) 住院的个人数据的分析.
- 后勤回归模型被用来探索基于CBC的炎症指标和GU之间的相关性.
- 采用接收器操作特征 (ROC) 曲线分析和处罚回归技术 (LASSO,逐步回归) 来评估预测能力并确定重要指标.
主要成果:
- 中性粒细胞与淋巴细胞比率,单细胞与淋巴细胞比率,全身免疫炎症指数,全身炎症反应指数 (SIRI) 和全身炎症总指数的升高水平与GU患病率的增加显著相关.
- 血小板与淋巴细胞的比率仅在完全调整的模型中显示出意义.
- SIRI表现出最高的区分能力,曲线下的面积 (AUC) 为0.868.8.
结论:
- 来自CBC测试的血液学指标显示,与GU患病率存在显著的相关性.
- 系统性炎症反应指数 (SIRI) 显示了与GU最突出的关联.
- 这些CBC衍生标记可以作为实际工具,用于识别患GU风险较高的个体.
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