在抗菌素耐药性的背景下,对益生菌菌株的表型和基因型表征
Ádám Kerek1,2, Nikolett Palkovicsné Pézsa1,2, Eszter Kaszab2,3,4
1Department of Pharmacology and Toxicology, University of Veterinary Medicine, Budapest, Hungary.
Frontiers in veterinary science
|October 20, 2025
概括
在动物和人类健康中使用的益生菌细菌可以携带抗菌素耐药性基因 (ARG). 这项研究在几个益生菌菌株中发现了对关键抗生素的耐药性,强调需要仔细评估安全性.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 公共卫生 公共卫生
背景情况:
- 抗菌素耐药性 (AMR) 是一个日益增长的全球健康威胁.
- 兽医和人类医学中的益生菌微生物可能携带AMR.
研究的目的:
- 描述工业益生菌菌株的表型和基因型抗微生物耐药性概况.
- 在这些益生菌中识别抗菌素耐药性基因 (ARG).
主要方法:
- 使用最小抑制度 (MIC) 测试评估的表型耐药性.
- 通过全基因组测序进行的基因型分析.
- 分析了五种益生菌菌株:Enterococcus faecium,Bacillus licheniformis,Bacillus subtilis,Lactobacillus rhamnosus和Pediococcus acidilactici. 这五种益生菌菌株包括:
主要成果:
- 多种菌株对临床相关的抗生素 (丁胺素,阿莫西西林,泰洛辛,佛洛芬尼科尔) 产生了耐药性.
- 全基因组测序检测出27种不同的ARG,主要与排泄和目标修改有关.
- *白杆菌 (Bacillus licheniformis) *表现出最多样化的ARG概况; *白杆菌 (Pediococcus acidilactici) *没有可检测的ARG.
结论:
- 益生菌菌株可以具有显著的抗微生物耐药性.
- 综合表型和基因型分析对于确保益生菌的安全性至关重要.
- 这项研究为动物和人类卫生保健中益生菌的安全应用提供了信息.
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